2026-10-05T11:32:20Z https://api.figshare.com/v2/oai

oai:figshare.com:article/34069461 2026-10-05T11:32:09Z category_27175 portal_0 item_type_3 month_year_10_2026

10.6084/m9.figshare.34069461.v1 Full Reproducible Search Strategies for IV Placement Review Full Reproducible Search Strategies for IV Placement Review IV placement distress pain anxiety children CC BY 4.0 1 Melis Lydston Lydston, Melis (2026). Full Reproducible Search Strategies for IV Placement Review. figshare. Dataset. https://doi.org/10.6084/m9.figshare.34069461.v1 figshare

oai:figshare.com:article/33954808 2026-10-05T11:32:08Z category_26161 portal_0 item_type_12 month_year_10_2026

10.6084/m9.figshare.33954808.v2 Integrating Evidence for Education Excellence - An Integrative Conceptual Review and Framework Development for K–12 Education - Academic Summary This academic summary presents the central argument, review approach and conceptual framework of Integrating Evidence for Education Excellence. The study examines how evidence from different research traditions can inform a coherent account of educational excellence and support diagnosis and improvement across K–12 education.Using an integrative conceptual review of published literature, the study brings together Eight Evidence Streams and develops five propositions connecting educational purpose, outcomes, institutional and professional capabilities, evidence interpretation and improvement. Its framework spans four connected levels of educational responsibility: system, school, leadership and teaching.The distinctive contribution is the integration of seven functions linking evidence and educational purpose with developmental diagnosis, Evidence Confidence, Excellence Distance, imperatives, contextual priorities, implementation and continuous learning. The summary explains the research foundations and reasoning supporting these relationships, positions the framework alongside established educational approaches, and outlines a programme of empirical evaluation.The publication provides researchers, policymakers, school leaders and educators with a shared conceptual basis for understanding excellence, interpreting evidence and connecting educational judgements with practical improvement. education excellence; integrative conceptual review; education improvement; evidence interpretation; developmental diagnosis CC BY 4.0 1 Hesham Metwalli Metwalli, Hesham (2026). Integrating Evidence for Education Excellence - An Integrative Conceptual Review and Framework Development for K–12 Education - Academic Summary. figshare. Preprint. https://doi.org/10.6084/m9.figshare.33954808.v2 figshare

oai:figshare.com:article/34069458 2026-10-05T11:30:58Z category_34133 portal_96 item_type_6 month_year_10_2026

10.6084/m9.figshare.34069458.v1 Full Bibliography from CHARLES WEISSMANN. 14 October 1931—11 December 2025 Weissmann publications.pdf 20th century CC BY 4.0 1 Piet Borst CBE 2 Richard A. Flavell FRS Borst CBE, Piet; Flavell FRS, Richard A. (2026). Full Bibliography from CHARLES WEISSMANN. 14 October 1931—11 December 2025. The Royal Society. Journal contribution. https://doi.org/10.6084/m9.figshare.34069458.v1 The Royal Society

oai:figshare.com:article/34069452 2026-10-05T11:30:26Z category_4 category_19 category_21 category_39 category_46 category_106 category_133 category_272 category_873 portal_87 item_type_3 month_year_10_2026

10.6084/m9.figshare.34069452.v1 Process-dependent chemical fingerprints and acute oral toxicity of four crude extracts of Edgeworthia gardneri (Wall.) Meisn in mice Edgeworthia gardneri (Wall.) Meisn is used as a Tibetan herbal tea and medicinal resource, but safety information is scarce. Four flower extracts from water decoction, water flash extraction (WFE), alcohol reflux, and alcohol flash extraction (AFE) (water decoction extract (WDE), WFE, alcohol reflux extract (ARE), and AFE, respectively) underwent preliminary acute oral toxicity assessment and high-performance liquid chromatography (HPLC) fingerprint-based chemical characterization. C57BL/6J mice were randomly assigned to a vehicle control or four extract groups (n = 10 per group; five males and five females); extract groups received a single oral dose of 1500 mg/kg. Animals were observed for 14 days; clinical signs, mortality, body weight, organ weights and coefficients, serum biochemical indices, and liver and kidney histopathology were assessed. HPLC fingerprinting identified 28 common peaks; peak responses and similarities differed among extracts, with WFE showing the greatest chromatographic deviation. No mortality or persistent signs of acute toxicity were observed. Body weight increased progressively without sustained suppression attributable to any extract. Organ coefficients and serum biochemical measurements showed sporadic changes without concordant toxicological significance. In male WDE-treated mice, serum aspartate aminotransferase (AST) increased, whereas alanine aminotransferase (ALT) and alkaline phosphatase (ALP) remained unchanged, and blinded liver scores did not indicate treatment-related injury. Under the tested single-dose conditions, the four E. gardneri flower extracts produced minimal evidence of acute oral toxicity in mice of either sex at 1500 mg/kg extract (crude-herb equivalents: 4.6–13.8 g/kg). These findings provide a reference for dose selection and methodology in future comparative safety assessments of different extraction processes. Compositional variations among extracts were noted, and their relevance to safety warrants further study. Edgeworthia gardneri (Wall.) Meisn acute oral toxicity crude extract extraction process HPLC fingerprint sex-stratified analysis CC BY 4.0 1 Zhenxing Zhou 2 Xinke Deng 3 Jun He 4 Bengui Ye 5 Lijuan Nie Process-dependent chemical fingerprints and acute oral toxicity of four crude extracts of Edgeworthia gardneri (Wall.) Meisn in mice. Taylor & Francis. Zhou, Zhenxing; Deng, Xinke; He, Jun; Ye, Bengui; Nie, Lijuan. Taylor & Francis This research was supported by the Xizang Natural Science Foundation (Grant number XZ202601ZR0115) and the Lhasa Science and Technology Plan Project (Grant number LSKJ202444). 31402719

oai:figshare.com:article/34069407 2026-10-05T11:27:39Z category_24490 portal_0 item_type_3 month_year_10_2026

10.6084/m9.figshare.34069407.v1 Comparative immediate post-treatment outcomes of mandibular mini-implant-supported multiloop edgewise archwire therapy in skeletal Class II malocclusion: a non-randomized bidirectional cohort study Objective: To compare immediate post-treatment cephalometric and patient-reported outcomes of MEAW therapy with mandibular mini-implant-supported modified Class II elastics versus MEAW therapy with conventional long Class II elastics in patients with skeletal Class II malocclusion and deep overbite. Methods: This non-randomized bidirectional cohort study included 20 patients (10 per group). Lateral cephalometric radiographs were obtained before and after treatment. The experimental group received MEAW with mandibular mini-implant-supported modified Class II elastics, whereas the control group received MEAW with conventional long Class II elastics. Patient-reported outcomes were assessed with a study-specific questionnaire. The primary comparative analysis used analysis of covariance (ANCOVA), with the post-treatment measurement as the outcome, treatment group as the main predictor, and the corresponding pretreatment measurement as a covariate. Unadjusted change-score comparisons were retained as secondary descriptive analyses. Multiplicity across the 17 cephalometric outcomes was addressed using Bonferroni and Benjamini-Hochberg false discovery rate (FDR) procedures; questionnaire domains were compared using Mann-Whitney U tests with FDR adjustment. Results: All patients met the predefined clinical finishing criteria of normal overjet and overbite with bilateral Class I canine and molar relationships. Several cephalometric variables were imbalanced at baseline. In secondary unadjusted change-score analyses, PP-FH, U1-L1, FMIA, IMPA, and ODI remained significant after Bonferroni correction. In the baseline-adjusted ANCOVA, however, only mandibular-incisor variables remained robust after Bonferroni correction: the adjusted experimental-versus-control difference was +29.35 degrees for FMIA (95% CI, 19.37 to 39.33; P < 0.001) and -25.28 degrees for IMPA (95% CI, -35.88 to -14.68; P < 0.001). U1-L1 remained nominally significant after baseline adjustment (+15.05 degrees; 95% CI, 1.69 to 28.41; P = 0.029) but did not survive multiplicity correction. Adjusted differences in PP-FH, ODI, ANB, and Wits were not statistically significant. After FDR correction of the questionnaire domains, doctor behavior and treatment knowledge remained significantly different between groups. Conclusions: In this small non-randomized cohort, the strongest baseline-adjusted finding was improved mandibular-incisor control with the mini-implant-supported MEAW protocol, reflected by more favorable FMIA and IMPA outcomes. Unadjusted differences in deep-overbite-related and vertical measurements were substantially attenuated after baseline adjustment, and evidence for superior sagittal skeletal correction was weak. Because the two protocols differed in both anchorage source and point of force application, the observed differences cannot be attributed to the mini-implant alone. Larger prospectively controlled studies with growth assessment and longer follow-up are required.[A1] [A2] [A1]Please verify the FDR-corrected questionnaire results. The Statistical Analysis section describes FDR correction only for the cephalometric comparisons, and the corrected P values for the questionnaire outcomes are not reported. In addition, based on the P values currently shown in Table 4, please recheck whether “treatment feeling” remains significant after Benjamini-Hochberg correction. Please report the corrected P values and ensure that the Abstract, Methods, Results, and Table 4 agree. [A2]Thank you for identifying this inconsistency. We rechecked the questionnaire analyses and applied the Benjamini–Hochberg false discovery rate (FDR) correction across all eight questionnaire domains based on the P values from the two-sided Mann–Whitney U tests. The FDR-adjusted P values were as follows: Daily Life Impact, 0.392; Doctor Behavior, 0.013; Treatment Knowledge, 0.006; Treatment Feeling, 0.057; Reason for Treatment Choice, 0.216; Treatment Motivation, 0.167; Treatment Concern, 0.880; and Level of Care, 0.057. Accordingly, Treatment Feeling did not remain statistically significant after FDR correction. Only Doctor Behavior and Treatment Knowledge remained statistically significant after correction. We have revised the Statistical Analysis section to explicitly state that the Benjamini–Hochberg procedure was applied across the eight questionnaire domains, and the corrected P values are now reported in Table 4. The Abstract and Results have also been revised to ensure consistency with Table 4. The separate overall-satisfaction item was analyzed independently and was not included in the FDR correction across the eight questionnaire domains. skeletal Class II malocclusion deep overbite multiloop edgewise arch wire mini-implant anchorage camouflage treatment CC BY 4.0 1 Guoxin Cai 2 Zitong Zhang 3 Ruini Lin Cai, Guoxin; Zhang, Zitong; Lin, Ruini (2026). Comparative immediate post-treatment outcomes of mandibular mini-implant-supported multiloop edgewise archwire therapy in skeletal Class II malocclusion: a non-randomized bidirectional cohort study. figshare. Dataset. https://doi.org/10.6084/m9.figshare.34069407.v1 figshare

oai:figshare.com:article/34031640 2026-10-05T11:27:21Z category_31475 category_37043 category_37076 category_37103 portal_289 item_type_6 month_year_10_2026

10779/uos.34031640.v1 Using functional MRI neurofeedback to modulate self-blame in major depressive disorder: a pilot study Background: Growing evidence implicates self-blame-related neural networks in the pathophysiology of major depressive disorder (MDD). fMRI neurofeedback is an emerging technology with the potential to deliver interventions targeting the neural substrates of self-blame, but its feasibility and potential mechanism in current MDD remain unresolved. Methods: The current pilot study employed a single-session, exploratory neurofeedback trial harnessing the subgenual cingulate cortex (SCC) BOLD activity as the sole training target. Two active interventions were compared. In Intervention A ( n = 10), participants were encouraged during neurofeedback to upregulate their SCC activity during a ‘guilt’ task and downregulate it during an ‘indignation’ task. In Intervention B ( n = 10), participants were encouraged to do the opposite. Results: Clinical scores improved significantly across interventions, although no significant intervention differences were detected. Neurofeedback performance was variable across participants and conditions, with significant group-level regulation in the intended direction observed only for the indignation condition in Intervention B. A whole-brain analysis using a uniform preprocessing pipeline revealed no clusters surviving correction for multiple comparisons. Conclusion: The results support the feasibility of the protocol and suggest that engagement with negative autobiographical memories during SCC-oriented neurofeedback can be delivered safely in this small sample. Group-level target engagement was inconsistent, but the observation that SCC regulation was most achievable during indignation tentatively suggests this region may be more functionally heterogeneous for causal agency representations than commonly assumed. The absence of significant whole-brain effects under a uniform pipeline indicates that any neural changes were not robust at the group level in this small sample. In summary, the study provides preliminary feasibility and safety data, alongside estimates of variance, to inform more adequately powered investigations into SCC-oriented neurofeedback for depression. Depression Guilt Indignation Self-blame Subgenual cingulate cortex fMRI neurofeedback Humans Neurofeedback Pilot Projects Major Depressive Disorder Magnetic Resonance Imaging Female Male Adult Gyrus Cinguli Brain Mapping Middle Aged Young Adult 5202 Biological Psychology 52 Psychology Mental Illness Clinical Research Neurosciences Behavioral and Social Science Biomedical Imaging Serious Mental Illness Brain Disorders Clinical Trials and Supportive Activities Mental Health 1109 Neurosciences 3209 Neurosciences 5203 Clinical and health psychology CC BY 4.0 1 Alex Nagle 2 Alessandro Colasanti 3 Roland Zahn 4 Chris Racey 5 Michael Lührs 6 Samira Bouyagoub 7 Christina Kampoureli 8 Jorge Moll 9 James Stone Nagle, Alex; Colasanti, Alessandro; Zahn, Roland; Racey, Chris; Lührs, Michael; Bouyagoub, Samira; et al. (2026). Using functional MRI neurofeedback to modulate self-blame in major depressive disorder: a pilot study. University of Sussex. Journal contribution. https://hdl.handle.net/10779/uos.34031640.v1 University of Sussex University of Brighton 21663768

oai:figshare.com:article/33617434 2026-10-05T11:26:34Z category_24187 portal_0 item_type_3 month_year_10_2026

10.6084/m9.figshare.33617434.v1 Chromosome-level genome assembly and karyotype validation of the tea tussock moth Euproctis pseudoconspersa The tea tussock moth, Euproctis pseudoconspersa, is an important defoliating pest of tea plants and various economically important crops. However, nuclear genomic resources suitable for investigating chromosome evolution, population genetics, and host adaptation in this species remain limited. In this study, we integrated PacBio HiFi, Hi-C, and Illumina RNA-sequencing data to generate a chromosome-level reference genome for E. pseudoconspersaand obtained independent cytogenetic evidence through the preparation of mitotic metaphase chromosomes. The final assembly spanned 356.85 Mb, with contig and scaffold N50 values of 10.22 and 16.80 Mb, respectively. In total, 99.9% of the assembled sequence was anchored to 22 chromosome-scale pseudomolecules. Karyotype analysis revealed a diploid chromosome number of 2n = 44, consistent with the 22 haploid chromosome-scale pseudomolecules supported by the Hi-C data. Genome completeness was estimated at 99.0% using BUSCO and 99.12% using compleasm, while the Merqury quality values exceeded 67.42. A total of 14,216 protein-coding genes were predicted. The raw sequencing data, chromosome-level genome assembly, karyotype images, gene annotations, and genome quality-assessment files generated in this study have been made publicly available. These resources provide a robust and reusable foundation for comparative genomics, chromosome evolution, host adaptation, and pest-management research in E. pseudoconspersaand related lepidopteran insects. genomic alterations Telomerase reactivation CC BY 4.0 yesong ren 1 yesong ren ren, yesong (2026). Chromosome-level genome assembly and karyotype validation of the tea tussock moth Euproctis pseudoconspersa. figshare. Dataset. https://doi.org/10.6084/m9.figshare.33617434.v1 figshare This work was supported by the Hunan Provincial Forestry Science and Technology Research & Innovation Project (Outstanding Young Talent Cultivation Program) (XLK202609), Seed Industry Special Projects for Yuelu Shan Laboratory (YLS-2025-ZY02048). 31275448

oai:figshare.com:article/34069377 2026-10-05T11:26:20Z category_30217 portal_0 item_type_12 month_year_10_2026

10.6084/m9.figshare.34069377.v1 Creation and Collapse Mechanism: Forward and Reverse Pathways, Quantization, and the 2.8\,M_\odot Fundamental Black Hole Unit This work presents a comprehensive, plain-language framework detailing the symmetrical relationship between the forward construction of matter and its gravitational reversal. The hypothesis outlines a five-part model spanning from fundamental fields to black hole formation: Part 1: Building (Forward): Matter is constructed in four distinct steps, each governed by a fundamental force of nature. Starting from the Higgs field and strong force (gluons) providing quark masses, through weak interactions (Z boson) forming neutrons, magnetism/W boson processes, to electromagnetism (photons) forming atoms. Part 2: The Window of Life: Chemistry, molecules, biology, and complexity emerge during a finite window of time sustained by stellar pressure balance and nuclear fusion. Part 3: Stellar Collapse & Quantization: As fusion consumes fuel in increasingly smaller core regions, it ultimately transitions from energy-releasing to energy-absorbing. Analogous to nuclear quantization in helium synthesis, the collapse rejects excess mass as energy, forming a fundamental quantized black hole unit. Part 4: Reversal by Gravity (Reverse): Gravity reverses the construction steps in exact succession—destroying atoms (white dwarf stage), executing electron capture via W bosons, releasing quarks via deconfinement, reducing strong force binding, and returning the Higgs field value to zero (v \rightarrow 0). Part 5: The 2.8\,M_\odot Fundamental Unit: The initial black hole forms a fundamental unit of approximately 2.8 solar masses, acting as a baseline structure for larger formations. Author: Marcin Słowik (Independent Researcher, Zielona Góra, Poland) ORCID: 0009-0004-6707-4546 Date: October 2026 Black holes (Astronomy) Space and time CC BY 4.0 Marcin Słowik 1 Marcin Słowik Słowik, Marcin (2026). Creation and Collapse Mechanism: Forward and Reverse Pathways, Quantization, and the 2.8\,M_\odot Fundamental Black Hole Unit. figshare. Preprint. https://doi.org/10.6084/m9.figshare.34069377.v1 figshare

oai:figshare.com:article/34069404 2026-10-05T11:25:51Z category_1325 portal_316 item_type_1 month_year_10_2026

10.3389/fvets.2026.1918882.s001 Image 1_Stability and dermatological safety assessment of Cryptocarya alba (Peumo) and Laureliopsis philippiana (Tepa) essential oil-carrying dry shampoo formulations for dermal use in dogs.jpeg IntroductionAntibiotic resistance is a major concern in human and veterinary medicine, supporting the development of alternative topical products for companion animals. This study aimed to develop and evaluate essential oil (EO)-based dry shampoo formulations incorporating EOs from Cryptocarya alba and Laureliopsis philippiana as potential veterinary dermocosmetic platforms for canine skin care and complementary management of superficial pyoderma.MethodsStarch-based dry shampoo prototypes containing C. alba or L. philippiana EOs were developed using corn starch, tapioca starch, or their mixtures. Magnesium stearate (MgS) was evaluated as a functional excipient, and two mixing protocols were compared. Optimized formulations were subjected to physicochemical characterization, thermal, mechanical, and 9-month stability assessments, and in vitro antibacterial testing against Staphylococcus pseudintermedius. Preclinical dermal safety was evaluated in BALB/c mice through macroscopic irritation scoring, body weight monitoring, and histological analysis. Subsequently, an exploratory, randomized, controlled, blinded, four-arm parallel-group study was conducted in 32 client-owned dogs with superficial pyoderma allocated to receive SLP, SCA, vehicle shampoo, or a chlorhexidine-based reference treatment for 21 days.ResultsMgS improved formulation homogeneity, fluidity, and reduced agglomeration, while the selected mixing protocol enhanced overall powder performance. The optimized formulations showed preliminary physical stability, although progressive changes in texture, fluidity, agglomeration tendency, and aroma were observed during storage. In vitro antibacterial activity was assay-dependent: no measurable inhibition zones were observed by agar diffusion, whereas serial dilution and viable-count assays showed concentration-dependent reductions in bacterial recovery, including effects associated with the vehicle formulation. No macroscopic or histological signs of dermal irritation were observed in mice. In dogs, the formulations were well tolerated under the evaluated conditions. Microbiological outcomes differed numerically among groups but not significantly; among the EO-containing formulations, SCA showed the most favorable exploratory profile, including culture negativity in 3/8 dogs and the highest proportion of dogs reaching a non-significant bacterial burden.DiscussionThese findings support the feasibility of incorporating C. alba and L. philippiana EOs into starch-based dry shampoo prototypes and provide preliminary evidence of physical stability and dermal tolerability. However, the assay-dependent antibacterial response, alkaline formulation pH, limited batch replication, and exploratory clinical design preclude conclusions regarding clinical efficacy. Further studies should include formulation optimization, quantitative chemical stability assessment, dermal permeation studies, and larger randomized controlled clinical trials. essential oils Cryptocarya alba Laureliopsis philippiana dry shampoo canine superficial pyoderma Staphylococcus pseudintermedius CC BY 4.0 1 Martín Varas 2 Martina Jacobs 3 Nicole Rojas 4 Paola Ramos 5 Flavia Bruna 6 Gabriela Valenzuela-Barra 7 Olosmira Correa 8 Antonia Díaz-Parra 9 Manuel Ahumada 10 Gabriela Maturana 11 Irene Martínez 12 Francisco Abusleme 13 Belén Rivera 14 María Olga Bargsted 15 Daniela Siel 16 Jessica Bravo Varas, Martín; Jacobs, Martina; Rojas, Nicole; Ramos, Paola; Bruna, Flavia; Valenzuela-Barra, Gabriela; et al. (2026). Image 1_Stability and dermatological safety assessment of Cryptocarya alba (Peumo) and Laureliopsis philippiana (Tepa) essential oil-carrying dry shampoo formulations for dermal use in dogs.jpeg. Frontiers. Figure. https://doi.org/10.3389/fvets.2026.1918882.s001 Frontiers

oai:figshare.com:article/33442582 2026-10-05T11:25:12Z category_24601 category_27142 category_28846 portal_0 item_type_3 month_year_10_2026

10.6084/m9.figshare.33442582.v1 DentDES: code, synthetic data and results for a factorial discrete-event evaluation of appointment spacing and readiness-aware dispatch in dental clinics Code, synthetic input data, archived results and diagnostics for the paper "DentDES: A Factorial Discrete-Event Evaluation of Appointment Spacing and Readiness-Aware Dispatch in Dental Clinics" (ISMSIT 2026).The Python and SimPy model compares two appointment-spacing rules and two dispatch rules (strict first-come-first-served and readiness-aware dispatch with a bypass bound of two) across four demand levels and three instrument-kit capacities. Each condition has 50 paired replication blocks of 30 clinic days (72,000 clinic-day runs). The archive also contains 36,000 exploratory diagnostic runs, validation scripts and recorded checks.All inputs are synthetic and no patient data were used. Results describe the model and are not estimates of effects in a real clinic. Code is MIT-licensed. Data, results and documentation are CC BY 4.0. See README.md to reproduce and validate: python validate.py --replay-all. dental operations discrete-event simulation appointment scheduling instrument availability patient flow resource coordination paired experiments healthcare operations synthetic data SimPy CC BY 4.0 Mehmet Ali Akyol 1 Mehmet Ali Akyol Fatemeh Astaraki 2 Fatemeh Astaraki Akyol, Mehmet Ali; Astaraki, Fatemeh (2026). DentDES: code, synthetic data and results for a factorial discrete-event evaluation of appointment spacing and readiness-aware dispatch in dental clinics. figshare. Dataset. https://doi.org/10.6084/m9.figshare.33442582.v1 figshare eyJtZXRhZGF0YVByZWZpeCI6ICJyZGYiLCAidmVyYiI6ICJMaXN0UmVjb3JkcyIsICJvYWlfaGFuZGxlciI6IHRydWUsICJuZWVkc19tZXRhZGF0YSI6IGZhbHNlLCAicGFnZSI6IDIsICJ4Q3Vyc29yIjogIklsc3hOemt4TVRrNU5URXlNREF3TENBek16UTBNalU0TWwwaS5fSkhlSEwxOFNWVWFkcGhRNXBxa0I5STRYajQiLCAiZXhwaXJhdGlvbiI6ICIyMDI2LTEwLTA1IDEyOjMyOjIwIn0=