2026-04-29T07:08:46Z https://api.figshare.com/v2/oai

oai:figshare.com:article/32121551 2026-04-29T06:37:34Z category_7 category_8 category_12 category_16 category_46 category_61 category_106 category_135 category_873 portal_87 item_type_6 month_year_04_2026

ICSI shows no advantage over conventional IVF in patients with unexpected low oocyte yield Mingzhao Li (8078720) Wennan Chen (23809004) Xia Xue (123975) Juanzi Shi (663812) Medicine Microbiology Cell Biology Physiology Immunology Developmental Biology Science Policy Computational Biology Chemical Sciences not elsewhere classified C-IVF ICSI oocyte yield reproductive outcomes A yield of fewer than five oocytes is associated with a sharp drop in success rates, making each oocyte extremely valuable and demanding highly efficient utilization. Therefore, we aimed to explore the optimal fertilization method for these patients. This retrospective cohort single-center study included 424 C-IVF cycles and 90 ICSI cycles from 2016 to 2023. All patients were in their first ART cycle, with 3 or 4 oocytes retrieved. The study subjects were primarily divided into two groups: the IVF-LN (C-IVF with a 50% lower-than-expected oocyte yield) group and the ICSI-LN (ICSI with a 50% lower-than-expected oocyte yield) group. We observed no significant differences in the day 3 available embryo (87.0 versus 84.8%; p = 0.41), blastocyst formation (61.2 versus 57.9%; p = 0.69), day 5 blastocyst (56.9 versus 54.5%; p = 0.83) or good quality blastocyst (45.4 versus 50.0%; p = 0.83) rates between the IVF-LN and ICSI-LN groups. However, the day 3 good quality embryo rate was significantly higher in the IVF-LN group than in the ICSI-LN group (59.76% vs. 47.46%; p < 0.01). There were no significant differences in the pregnancy (61.8 versus 57.7%; p = 0.50), clinical pregnancy (59.1 versus 53.8%; p = 0.40), ongoing pregnancy (52.2 versus 47.4%; p = 0.45) or live birth (48.6 versus 44.9%; p = 0.55) rates between the IVF-LN and ICSI-LN groups. For patients with <5 Oocytes and a predicted yield of ≤50%, ICSI did not demonstrate a significant advantage over C-IVF. 2026-04-29T06:37:34Z Text Journal contribution 10.6084/m9.figshare.32121551.v1 https://figshare.com/articles/journal_contribution/ICSI_shows_no_advantage_over_conventional_IVF_in_patients_with_unexpected_low_oocyte_yield/32121551 CC BY 4.0 open access http://purl.org/coar/access_right/c_abf2

oai:figshare.com:article/32121548 2026-04-29T06:35:30Z category_1 category_4 category_7 category_12 category_13 category_14 category_15 category_19 category_21 category_39 category_64 category_146 category_734 category_873 category_931 portal_87 item_type_6 month_year_04_2026

Exploring the therapeutic potential of ethyl acetate fractions from algerian propolis against neuroblastoma: chemical profile, in vitro bioactivities and in silico inhibition of MDM2-P53 interaction Safia Boulechfar (17701524) Mehmet Enes Arslan (15238307) Amar Zellagui (825779) Mehmet Öztürk (825778) El Hassen Mokrani (19939881) Gürkan Berber (23808992) Dilara Esra Men (23808995) Karima Oufroukh (23808998) Hatice Karataş (23809001) Biophysics Biochemistry Medicine Cell Biology Genetics Molecular Biology Neuroscience Pharmacology Biotechnology Ecology Cancer Space Science Biological Sciences not elsewhere classified Chemical Sciences not elsewhere classified Information Systems not elsewhere classified Propolis neuroblastoma SH-SY5Y apoptosis MDM2 molecular docking molecular dynamics In this work, we evaluated the chemical composition and the potential of ethyl acetate fractions of propolis from Babor (EAFPB) and El-Menia (EAFPM) regions against human neuroblastoma SH-SY5Y. The inhibitory of MDM2-P53 interaction by propolis phytochemicals was also evaluated by molecular docking and molecular dynamics simulations. HPLC-DAD revealed the predominance of phenolic acids such as vanillic acid, p-coumaric acid, cynarin; and flavonoids such as naringenin, hesperetin and hesperidin. Besides, fumaric acid and esculetin were detected for the first time in Algerian propolis. In vitro studies validated the selective anticancer and apoptotic properties of propolis fractions, and confirmed the absence of genotoxic effects. Molecular docking and molecular dynamics revealed good binding affinities and stable interactions of Kaempferol, Naringenin, Hesperetin, Apigenin and Luteolin with MDM2. Overall, the findings highlight the potential of Algerian propolis-derived compounds as selective anticancer agents against neuroblastoma. 2026-04-29T06:35:30Z Text Journal contribution 10.6084/m9.figshare.32121548.v1 https://figshare.com/articles/journal_contribution/Exploring_the_therapeutic_potential_of_ethyl_acetate_fractions_from_algerian_propolis_against_neuroblastoma_chemical_profile_i_in_vitro_i_bioactivities_and_i_in_silico_i_inhibition_of_MDM2-P53_interaction/32121548 CC BY 4.0 open access http://purl.org/coar/access_right/c_abf2

oai:figshare.com:article/32121535 2026-04-29T06:30:10Z category_33749 portal_96 item_type_6 month_year_04_2026

Appendix from Management history can cause irreversible changes in agroecosystems: insights from an extended Carpenter model Athmanathan Senthilnathan (23808982) Theresa Wei Ying Ong (9019370) Other environmental sciences not elsewhere classified Environmental Science Biomathematics appendix.pdf 2026-04-29T06:30:10Z Text Journal contribution 10.6084/m9.figshare.32121535.v1 https://figshare.com/articles/journal_contribution/Appendix_from_Management_history_can_cause_irreversible_changes_in_agroecosystems_insights_from_an_extended_Carpenter_model/32121535 CC BY 4.0 embargoed access http://purl.org/coar/access_right/c_f1cf 2026-05-19

oai:figshare.com:article/31343677 2026-04-29T06:29:33Z category_24271 category_24310 portal_0 item_type_3 month_year_04_2026

Stickleback genome assemblies Dandan Wang (11534062) Phylogeny and comparative analysis Genomics Stickleback Genome This contains haplotype-resolved genome assemblies for Pungitius pungitius WL (Belgium and UK) 2026-04-29T06:29:33Z Dataset Dataset 10.6084/m9.figshare.31343677.v1 https://figshare.com/articles/dataset/Stickleback_genome_assemblies/31343677 CC BY 4.0 open access http://purl.org/coar/access_right/c_abf2

oai:figshare.com:article/32121529 2026-04-29T00:00:00Z category_1 category_7 category_734 category_811 category_873 category_931 portal_63 item_type_6 month_year_04_2026

Solvent Models and Charge Scaling: Benchmarks for Molecular Dynamics of Glycosaminoglycans Jacob A. Clark (23808976) Sergey A. Samsonov (1684066) Biophysics Medicine Biological Sciences not elsewhere classified Mathematical Sciences not elsewhere classified Chemical Sciences not elsewhere classified Information Systems not elsewhere classified various parameter choices finding dramatic differences glycosaminoglycan chain length high negative charge solvent model choice previous work within multiple solvent models charge scaling methods glycosaminoglycans glycosaminoglycans make solvent models solvent model charge scaling glycosaminoglycan simulations unbound glycosaminoglycans simulate glycosaminoglycans wide variety typical scenarios scaled approaches rigorously investigated physiological roles molecular dynamics limited understanding greater similarity forcefield sensitivity forcefield parameters distinct protocols conventional non computational approaches comprehensive understanding biomolecules requires ameliorated within also sensitive Glycosaminoglycans make up a group of highly negatively charged linear polysaccharides with a wide variety of physiological roles. Investigating these biomolecules requires both experimental and computational approaches. However, there is limited understanding of how various parameter choices in the design of simulations can impact the behavior of glycosaminoglycans. Previous work within our group has explored the impact of solvent model choice on unbound glycosaminoglycans and within their complexes with proteins, finding dramatic differences in results that depend on which solvent model is used. The high negative charge these molecules possess also poses a challenge, as the simulations become not only dependent on solvent model choice but also sensitive to changes in forcefield parameters. Charge scaling methods have been proposed to improve the accuracy of forcefields used to simulate glycosaminoglycans. In this study, the application of charge scaling methods within the context of the solvent model has been rigorously investigated with the goal of quantifying the impacts of distinct protocols in the analysis of protein–glycosaminoglycan interactions. Utilizing previous experimental data collected on glycosaminoglycan chain length for reference, it was found that charge-scaled simulations of heparin resulted in greater similarity to experimental properties than conventional non-charge-scaled approaches. This improvement in the simulated properties of heparin is maintained with multiple solvent models and under typical scenarios in which heparin may be simulated, along with characterization of the effects on protein–glycosaminoglycan binding, provides a more comprehensive understanding of how the challenge of solvent model choice and forcefield sensitivity can be ameliorated within the field of glycosaminoglycan simulations. 2026-04-29T00:00:00Z Text Journal contribution 10.1021/acs.jpcb.6c01164.s001 https://figshare.com/articles/journal_contribution/Solvent_Models_and_Charge_Scaling_Benchmarks_for_Molecular_Dynamics_of_Glycosaminoglycans/32121529 CC BY-NC 4.0 open access http://purl.org/coar/access_right/c_abf2

oai:figshare.com:article/32121502 2026-04-29T06:28:05Z category_24700 portal_0 item_type_3 month_year_04_2026

Sup Table Data Base Labo and Sup Table Data Base Medrio of the TrypSkin sub-study Brice Rotureau (23808937) Medical parasitology Dataset TrypSkin Detection of bloodstream and dermal trypanosomes in individuals seropositive but parasitologically unconfirmed for human African trypanosomiasis in Guinea and the Democratic Republic of the Congo (TrypSkin): a prospective sub-study of the Phase II/III DNDi-OXA-04-HAT trial. 2026-04-29T06:28:05Z Dataset Dataset 10.6084/m9.figshare.32121502.v1 https://figshare.com/articles/dataset/Sup_Table_Data_Base_Labo_and_Sup_Table_Data_Base_Medrio_of_the_TrypSkin_sub-study/32121502 CC BY 4.0 embargoed access http://purl.org/coar/access_right/c_f1cf 2026-10-29

oai:figshare.com:article/26932369 2022-03-01T00:00:00Z category_25666 portal_923 item_type_6 month_year_03_2022

Pivots, arts practice and potentialities: Creative engagement, community well-being and arts-led research during COVID-19 in Australia D Hancox (19533868) S Gattenhof (19533871) Sasha Mackay (11393510) H Klaebe (19533874) Performing arts not elsewhere classified Arts in health Community engagement COVID-19 Place-based culture Regional Australia Social isolation Pre-dating COVID-19 it was widely acknowledged that there was a loneliness epidemic and that prolonged loneliness and reduced human touch results in increased propensity to heart disease, stroke and clinical dementia. Given such statistics, and the use of isolation and shielding as a health response to the COVID-19 pandemic, it is imperative that creative projects or research investigations embed strategies to address the potential fragmentation of community and increased difficulty of social connection. This discussion examines two Australian art-based projects – ‘A Place in Our Art’ and ‘Shorewell Presents … Dear Friend’ – to illustrate the use of arts and cultural activities to maintain and support social connection. The article draws on arts-health and performance theory to unpack project design and outcomes of using both physical and virtual creative art-based engagement strategies in a crisis to entice continued participation and support well-being. 2022-03-01T00:00:00Z Text Journal contribution 10779/cqu.26932369.v2 https://figshare.com/articles/journal_contribution/Pivots_arts_practice_and_potentialities_Creative_engagement_community_well-being_and_arts-led_research_during_COVID-19_in_Australia/26932369 CC BY 4.0 open access http://purl.org/coar/access_right/c_abf2

oai:figshare.com:article/32121493 2026-04-29T06:24:26Z category_24727 category_26281 portal_0 item_type_3 month_year_04_2026

ANS Function Estimation (PONE-D-26-08299) Ruichen Li (18198001) Autonomic nervous system Computational physiology Interoceptive signals Autonomic nervous system modulation Autism spectrum disorder Computational model Respiratory modulation Research findings for the manuscript titled "Interoceptive autonomic regulation in typical development and autism spectrum disorder: A computational model integrating multiple physiological systems" 2026-04-29T06:24:26Z Dataset Dataset 10.6084/m9.figshare.32121493.v1 https://figshare.com/articles/dataset/ANS_Function_Estimation_PONE-D-26-08299_/32121493 CC BY 4.0 open access http://purl.org/coar/access_right/c_abf2

oai:figshare.com:article/32075238 2026-04-29T06:23:13Z category_24721 category_24748 category_27031 portal_0 item_type_1 month_year_04_2026

Supplemental Figures S1-S2: Differential Modulation of Reciprocal Inhibition Between Wrist Extensors and Flexors by Repetitive Peripheral Magnetic Stimulation of the Wrist Extensors Dai Miyazaki (23770461) Ayu Omiya (23770494) Kanau Shitar (23770497) Hiromi Fujii (23770499) Mitsuhiro Nito (21665192) Medical physiology not elsewhere classified Neurosciences not elsewhere classified Rehabilitation Forearm Muscle H-reflexe Spinal circuits This PDF file contains supplemental figures (Figures S1-S2) for the study titled "Differential Modulation of Reciprocal Inhibition Between Wrist Extensors and Flexors by Repetitive Peripheral Magnetic Stimulation of the Wrist Extensors". 2026-04-29T06:23:13Z Image Figure 10.6084/m9.figshare.32075238.v1 https://figshare.com/articles/figure/Supplemental_Figures_S1-S2_Differential_Modulation_of_Reciprocal_Inhibition_Between_Wrist_Extensors_and_Flexors_by_Repetitive_Peripheral_Magnetic_Stimulation_of_the_Wrist_Extensors/32075238 CC BY 4.0 open access http://purl.org/coar/access_right/c_abf2

oai:figshare.com:article/32121481 2026-04-29T06:21:12Z category_30094 category_30097 category_30100 category_30112 category_30121 category_30154 category_30229 portal_0 item_type_12 month_year_04_2026

Pp nf colaboration notes Mark Chrisman (23637490) Cosmology and extragalactic astronomy Galactic astronomy General relativity and gravitational waves Stellar astronomy and planetary systems Atomic and molecular physics Classical physics not elsewhere classified Foundations of quantum mechanics substrate models Pp nf is a model from one author, Mark Chrisman with the help of many a.I. platforms and serves as an experiment on many fronts. 2026-04-29T06:21:12Z Text Preprint 10.6084/m9.figshare.32121481.v1 https://figshare.com/articles/preprint/Pp_nf_colaboration_notes/32121481 CC BY 4.0 open access http://purl.org/coar/access_right/c_abf2 eyJtZXRhZGF0YVByZWZpeCI6ICJvYWlfZGMiLCAidmVyYiI6ICJMaXN0UmVjb3JkcyIsICJvYWlfaGFuZGxlciI6IHRydWUsICJwYWdlIjogMiwgInhDdXJzb3IiOiAiZXlKaGJHY2lPaUpJVXpVeE1pSjkuSWxzeE56YzNORFF6TmpjeU1EQXdMQ0F6TWpFeU1UUTRNVjBpLnhZMmo0eXlRRUpKODNSeExMWWdrTUpnRDdaV0FPWXdxcnQwWUU1M1RxaVpGcGNaUkZvdW9JbG5RMDVtbTBMZ1F1ZmxDc1puMDBJSGZkLWVNSUQtaDRRIiwgImV4cGlyYXRpb24iOiAiMjAyNi0wNC0yOSAwODowODo0NiJ9