2026-10-05T11:31:51Z https://api.figshare.com/v2/oai
oai:figshare.com:article/34069458 2026-10-05T11:30:58Z category_34133 portal_96 item_type_6 month_year_10_2026
10.6084/m9.figshare.34069458.v1 https://figshare.com/articles/journal_contribution/Full_Bibliography_from_CHARLES_WEISSMANN_14_October_1931_11_December_2025/34069458 https://ndownloader.figshare.com/files/69656049 10.1098/rsbm.2026.0019 Borst CBE, Piet Piet Borst CBE Flavell FRS, Richard A. Richard A. Flavell FRS <![CDATA[Full Bibliography from CHARLES WEISSMANN. 14 October 1931—11 December 2025]]> Historical studies not elsewhere classified 20th century 2026-10-05 2026-10-05 Journal contribution 2026 The Royal Society
oai:figshare.com:article/34069452 2026-10-05T11:30:26Z category_4 category_19 category_21 category_39 category_46 category_106 category_133 category_272 category_873 portal_87 item_type_3 month_year_10_2026
10.6084/m9.figshare.34069452.v1 https://figshare.com/articles/dataset/Process-dependent_chemical_fingerprints_and_acute_oral_toxicity_of_four_crude_extracts_of_i_Edgeworthia_gardneri_i_Wall_Meisn_in_mice/34069452 https://ndownloader.figshare.com/files/69656028 https://ndownloader.figshare.com/files/69656031 10.1080/01480545.2026.2737968 Zhou, Zhenxing Zhenxing Zhou Deng, Xinke Xinke Deng He, Jun Jun He Ye, Bengui Bengui Ye Nie, Lijuan Lijuan Nie <![CDATA[Process-dependent chemical fingerprints and acute oral toxicity of four crude extracts of <i>Edgeworthia gardneri</i> (Wall.) Meisn in mice]]> Biochemistry Pharmacology Biotechnology Ecology Immunology Science Policy Plant Biology Environmental Sciences not elsewhere classified Chemical Sciences not elsewhere classified Edgeworthia gardneri (Wall.) Meisn acute oral toxicity crude extract extraction process HPLC fingerprint sex-stratified analysis 2026-10-05 2026-10-05 Dataset 2026 Taylor & Francis Edgeworthia gardneri (Wall.) Meisn is used as a Tibetan herbal tea and medicinal resource, but safety information is scarce. Four flower extracts from water decoction, water flash extraction (WFE), alcohol reflux, and alcohol flash extraction (AFE) (water decoction extract (WDE), WFE, alcohol reflux extract (ARE), and AFE, respectively) underwent preliminary acute oral toxicity assessment and high-performance liquid chromatography (HPLC) fingerprint-based chemical characterization. C57BL/6J mice were randomly assigned to a vehicle control or four extract groups (n = 10 per group; five males and five females); extract groups received a single oral dose of 1500 mg/kg. Animals were observed for 14 days; clinical signs, mortality, body weight, organ weights and coefficients, serum biochemical indices, and liver and kidney histopathology were assessed. HPLC fingerprinting identified 28 common peaks; peak responses and similarities differed among extracts, with WFE showing the greatest chromatographic deviation. No mortality or persistent signs of acute toxicity were observed. Body weight increased progressively without sustained suppression attributable to any extract. Organ coefficients and serum biochemical measurements showed sporadic changes without concordant toxicological significance. In male WDE-treated mice, serum aspartate aminotransferase (AST) increased, whereas alanine aminotransferase (ALT) and alkaline phosphatase (ALP) remained unchanged, and blinded liver scores did not indicate treatment-related injury. Under the tested single-dose conditions, the four E. gardneri flower extracts produced minimal evidence of acute oral toxicity in mice of either sex at 1500 mg/kg extract (crude-herb equivalents: 4.6–13.8 g/kg). These findings provide a reference for dose selection and methodology in future comparative safety assessments of different extraction processes. Compositional variations among extracts were noted, and their relevance to safety warrants further study.

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oai:figshare.com:article/34069407 2026-10-05T11:27:39Z category_24490 portal_0 item_type_3 month_year_10_2026
10.6084/m9.figshare.34069407.v1 https://figshare.com/articles/dataset/Comparative_immediate_post-treatment_outcomes_of_mandibular_mini-implant-supported_multiloop_edgewise_archwire_therapy_in_skeletal_Class_II_malocclusion_a_non-randomized_bidirectional_cohort_study/34069407 https://ndownloader.figshare.com/files/69655842 Cai, Guoxin Guoxin Cai Zhang, Zitong Zitong Zhang Lin, Ruini Ruini Lin <![CDATA[Comparative immediate post-treatment outcomes of mandibular mini-implant-supported multiloop edgewise archwire therapy in skeletal Class II malocclusion: a non-randomized bidirectional cohort study]]> Dermatology skeletal Class II malocclusion deep overbite multiloop edgewise arch wire mini-implant anchorage camouflage treatment 2026-10-05 2026-10-05 Dataset 2026 figshare Objective: To compare immediate post-treatment cephalometric and patient-reported outcomes of MEAW therapy with mandibular mini-implant-supported modified Class II elastics versus MEAW therapy with conventional long Class II elastics in patients with skeletal Class II malocclusion and deep overbite. Methods: This non-randomized bidirectional cohort study included 20 patients (10 per group). Lateral cephalometric radiographs were obtained before and after treatment. The experimental group received MEAW with mandibular mini-implant-supported modified Class II elastics, whereas the control group received MEAW with conventional long Class II elastics. Patient-reported outcomes were assessed with a study-specific questionnaire. The primary comparative analysis used analysis of covariance (ANCOVA), with the post-treatment measurement as the outcome, treatment group as the main predictor, and the corresponding pretreatment measurement as a covariate. Unadjusted change-score comparisons were retained as secondary descriptive analyses. Multiplicity across the 17 cephalometric outcomes was addressed using Bonferroni and Benjamini-Hochberg false discovery rate (FDR) procedures; questionnaire domains were compared using Mann-Whitney U tests with FDR adjustment. Results: All patients met the predefined clinical finishing criteria of normal overjet and overbite with bilateral Class I canine and molar relationships. Several cephalometric variables were imbalanced at baseline. In secondary unadjusted change-score analyses, PP-FH, U1-L1, FMIA, IMPA, and ODI remained significant after Bonferroni correction. In the baseline-adjusted ANCOVA, however, only mandibular-incisor variables remained robust after Bonferroni correction: the adjusted experimental-versus-control difference was +29.35 degrees for FMIA (95% CI, 19.37 to 39.33; P < 0.001) and -25.28 degrees for IMPA (95% CI, -35.88 to -14.68; P < 0.001). U1-L1 remained nominally significant after baseline adjustment (+15.05 degrees; 95% CI, 1.69 to 28.41; P = 0.029) but did not survive multiplicity correction. Adjusted differences in PP-FH, ODI, ANB, and Wits were not statistically significant. After FDR correction of the questionnaire domains, doctor behavior and treatment knowledge remained significantly different between groups. Conclusions: In this small non-randomized cohort, the strongest baseline-adjusted finding was improved mandibular-incisor control with the mini-implant-supported MEAW protocol, reflected by more favorable FMIA and IMPA outcomes. Unadjusted differences in deep-overbite-related and vertical measurements were substantially attenuated after baseline adjustment, and evidence for superior sagittal skeletal correction was weak. Because the two protocols differed in both anchorage source and point of force application, the observed differences cannot be attributed to the mini-implant alone. Larger prospectively controlled studies with growth assessment and longer follow-up are required.[A1] [A2] [A1]Please verify the FDR-corrected questionnaire results. The Statistical Analysis section describes FDR correction only for the cephalometric comparisons, and the corrected P values for the questionnaire outcomes are not reported. In addition, based on the P values currently shown in Table 4, please recheck whether “treatment feeling” remains significant after Benjamini-Hochberg correction. Please report the corrected P values and ensure that the Abstract, Methods, Results, and Table 4 agree. [A2]Thank you for identifying this inconsistency. We rechecked the questionnaire analyses and applied the Benjamini–Hochberg false discovery rate (FDR) correction across all eight questionnaire domains based on the P values from the two-sided Mann–Whitney U tests. The FDR-adjusted P values were as follows: Daily Life Impact, 0.392; Doctor Behavior, 0.013; Treatment Knowledge, 0.006; Treatment Feeling, 0.057; Reason for Treatment Choice, 0.216; Treatment Motivation, 0.167; Treatment Concern, 0.880; and Level of Care, 0.057. Accordingly, Treatment Feeling did not remain statistically significant after FDR correction. Only Doctor Behavior and Treatment Knowledge remained statistically significant after correction. We have revised the Statistical Analysis section to explicitly state that the Benjamini–Hochberg procedure was applied across the eight questionnaire domains, and the corrected P values are now reported in Table 4. The Abstract and Results have also been revised to ensure consistency with Table 4. The separate overall-satisfaction item was analyzed independently and was not included in the FDR correction across the eight questionnaire domains.

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oai:figshare.com:article/33617434 2026-10-05T11:26:34Z category_24187 portal_0 item_type_3 month_year_10_2026
10.6084/m9.figshare.33617434.v1 https://figshare.com/articles/dataset/Chromosome-level_genome_assembly_and_karyotype_validation_of_the_tea_tussock_moth_Euproctis_pseudoconspersa/33617434 https://ndownloader.figshare.com/files/68456380 https://ndownloader.figshare.com/files/68456383 https://ndownloader.figshare.com/files/68456386 https://ndownloader.figshare.com/files/68456389 ren, yesong yesong ren 0000-0003-2173-2975 <![CDATA[Chromosome-level genome assembly and karyotype validation of the tea tussock moth Euproctis pseudoconspersa]]> Biological network analysis genomic alterations Telomerase reactivation 2026-10-05 2026-10-05 Dataset 2026 figshare The tea tussock moth, Euproctis pseudoconspersa, is an important defoliating pest of tea plants and various economically important crops. However, nuclear genomic resources suitable for investigating chromosome evolution, population genetics, and host adaptation in this species remain limited. In this study, we integrated PacBio HiFi, Hi-C, and Illumina RNA-sequencing data to generate a chromosome-level reference genome for E. pseudoconspersaand obtained independent cytogenetic evidence through the preparation of mitotic metaphase chromosomes. The final assembly spanned 356.85 Mb, with contig and scaffold N50 values of 10.22 and 16.80 Mb, respectively. In total, 99.9% of the assembled sequence was anchored to 22 chromosome-scale pseudomolecules. Karyotype analysis revealed a diploid chromosome number of 2n = 44, consistent with the 22 haploid chromosome-scale pseudomolecules supported by the Hi-C data. Genome completeness was estimated at 99.0% using BUSCO and 99.12% using compleasm, while the Merqury quality values exceeded 67.42. A total of 14,216 protein-coding genes were predicted. The raw sequencing data, chromosome-level genome assembly, karyotype images, gene annotations, and genome quality-assessment files generated in this study have been made publicly available. These resources provide a robust and reusable foundation for comparative genomics, chromosome evolution, host adaptation, and pest-management research in E. pseudoconspersaand related lepidopteran insects.

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oai:figshare.com:article/34069377 2026-10-05T11:26:20Z category_30217 portal_0 item_type_12 month_year_10_2026
10.6084/m9.figshare.34069377.v1 https://figshare.com/articles/preprint/Creation_and_Collapse_Mechanism_Forward_and_Reverse_Pathways_Quantization_and_the_2_8_M_odot_Fundamental_Black_Hole_Unit/34069377 https://ndownloader.figshare.com/files/69655809 Słowik, Marcin Marcin Słowik 0009-0004-6707-4546 <![CDATA[Creation and Collapse Mechanism: Forward and Reverse Pathways, Quantization, and the 2.8\,M_\odot Fundamental Black Hole Unit]]> Particle physics Black holes (Astronomy) Space and time 2026-10-05 2026-10-05 Preprint 2026 figshare This work presents a comprehensive, plain-language framework detailing the symmetrical relationship between the forward construction of matter and its gravitational reversal. The hypothesis outlines a five-part model spanning from fundamental fields to black hole formation: Part 1: Building (Forward): Matter is constructed in four distinct steps, each governed by a fundamental force of nature. Starting from the Higgs field and strong force (gluons) providing quark masses, through weak interactions (Z boson) forming neutrons, magnetism/W boson processes, to electromagnetism (photons) forming atoms. Part 2: The Window of Life: Chemistry, molecules, biology, and complexity emerge during a finite window of time sustained by stellar pressure balance and nuclear fusion. Part 3: Stellar Collapse & Quantization: As fusion consumes fuel in increasingly smaller core regions, it ultimately transitions from energy-releasing to energy-absorbing. Analogous to nuclear quantization in helium synthesis, the collapse rejects excess mass as energy, forming a fundamental quantized black hole unit. Part 4: Reversal by Gravity (Reverse): Gravity reverses the construction steps in exact succession—destroying atoms (white dwarf stage), executing electron capture via W bosons, releasing quarks via deconfinement, reducing strong force binding, and returning the Higgs field value to zero (v \rightarrow 0). Part 5: The 2.8\,M_\odot Fundamental Unit: The initial black hole forms a fundamental unit of approximately 2.8 solar masses, acting as a baseline structure for larger formations. Author:

Marcin Słowik (Independent Researcher, Zielona Góra, Poland) ORCID: 0009-0004-6707-4546 Date: October 2026

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oai:figshare.com:article/34069404 2026-10-05T11:25:51Z category_1325 portal_316 item_type_1 month_year_10_2026
10.3389/fvets.2026.1918882.s001 https://figshare.com/articles/figure/Image_1_Stability_and_dermatological_safety_assessment_of_Cryptocarya_alba_Peumo_and_Laureliopsis_philippiana_Tepa_essential_oil-carrying_dry_shampoo_formulations_for_dermal_use_in_dogs_jpeg/34069404 https://ndownloader.figshare.com/files/69655839 https://doi.org//10.3389/fmicb.2016.01599 https://doi.org//10.1111/vde.13342 https://doi.org//10.3390/microorganisms11030581 https://doi.org//10.3390/antibiotics9080444 https://doi.org//10.1371/journal.pone.0261884 https://doi.org//10.1111/vde.12118 https://doi.org//10.1016/j.micpath.2024.106975 https://doi.org//10.1016/j.foodchem.2022.134723 https://doi.org//10.1016/j.micpath.2025.107622 https://doi.org//10.3390/biom13071144 https://doi.org//10.1016/j.indcrop.2025.121411 https://doi.org//10.4067/S0717-97072016000300014 https://doi.org//10.1016/j.arabjc.2022.104271 https://doi.org//10.3390/molecules25235600 https://doi.org//10.2306/scienceasia1513-1874.2021.093 https://doi.org//10.3390/antibiotics12030506 https://doi.org//10.1136/vr.116.16.431 https://doi.org//10.1111/avj.70048 https://doi.org//10.1111/vde.70035 https://doi.org//10.3390/vetsci13060544 https://doi.org//10.18231/j.ijpca.2021.022 https://doi.org//10.5281/zenodo.3547000 https://doi.org//10.1208/s12249-013-0007-5 https://doi.org//10.1016/j.powtec.2023.118337 https://doi.org//10.1201/9781003032694 https://doi.org//10.1111/jocd.14269 https://doi.org//10.1159/000454919 https://doi.org//10.1016/j.micpath.2020.103980 https://doi.org//10.1152/physrev.00067.2017 https://doi.org//10.3389/fvets.2023.1137781 https://doi.org//10.1111/j.1365-3164.2010.00889.x https://doi.org//10.17305/bjbms.2007.3060 https://doi.org//10.1111/1750-3841.12492 https://doi.org//10.3389/fntpr.2025.1490511 https://doi.org//10.1046/j.1365-3164.2002.00312.x https://doi.org//10.24425/pjvs.2022141805 https://doi.org//10.1016/j.partic.2024.08.015 https://doi.org//10.1016/j.msec.2013.02.049 https://doi.org//10.3390/pharmaceutics13040558 https://doi.org//10.3390/medicines4020021 https://doi.org//10.3390/ani10101782 https://doi.org//10.1016/j.ijpharm.2024.124029 https://doi.org//10.1016/j.fct.2007.09.106 https://doi.org//10.3390/vetsci8010011 https://doi.org//10.1111/vde.12233 https://doi.org//10.1016/j.gaost.2019.03.001 https://doi.org//10.1016/j.tvjl.2013.11.014 https://doi.org//10.1093/jac/dkr367 https://doi.org//10.1016/j.vetmic.2018.09.013 https://doi.org//10.1016/j.jiph.2023.10.041 10.3389/fvets.2026.1918882 Varas, Martín Martín Varas Jacobs, Martina Martina Jacobs Rojas, Nicole Nicole Rojas Ramos, Paola Paola Ramos Bruna, Flavia Flavia Bruna Valenzuela-Barra, Gabriela Gabriela Valenzuela-Barra Correa, Olosmira Olosmira Correa Díaz-Parra, Antonia Antonia Díaz-Parra Ahumada, Manuel Manuel Ahumada Maturana, Gabriela Gabriela Maturana Martínez, Irene Irene Martínez Abusleme, Francisco Francisco Abusleme Rivera, Belén Belén Rivera Bargsted, María Olga María Olga Bargsted Siel, Daniela Daniela Siel Bravo, Jessica Jessica Bravo <![CDATA[Image 1_Stability and dermatological safety assessment of Cryptocarya alba (Peumo) and Laureliopsis philippiana (Tepa) essential oil-carrying dry shampoo formulations for dermal use in dogs.jpeg]]> Veterinary Anaesthesiology and Intensive Care essential oils Cryptocarya alba Laureliopsis philippiana dry shampoo canine superficial pyoderma Staphylococcus pseudintermedius 2026-10-05 2026-10-05 Figure 2026 Frontiers Antibiotic resistance is a major concern in human and veterinary medicine, supporting the development of alternative topical products for companion animals. This study aimed to develop and evaluate essential oil (EO)-based dry shampoo formulations incorporating EOs from Cryptocarya alba and Laureliopsis philippiana as potential veterinary dermocosmetic platforms for canine skin care and complementary management of superficial pyoderma.

Methods

Starch-based dry shampoo prototypes containing C. alba or L. philippiana EOs were developed using corn starch, tapioca starch, or their mixtures. Magnesium stearate (MgS) was evaluated as a functional excipient, and two mixing protocols were compared. Optimized formulations were subjected to physicochemical characterization, thermal, mechanical, and 9-month stability assessments, and in vitro antibacterial testing against Staphylococcus pseudintermedius. Preclinical dermal safety was evaluated in BALB/c mice through macroscopic irritation scoring, body weight monitoring, and histological analysis. Subsequently, an exploratory, randomized, controlled, blinded, four-arm parallel-group study was conducted in 32 client-owned dogs with superficial pyoderma allocated to receive SLP, SCA, vehicle shampoo, or a chlorhexidine-based reference treatment for 21 days.

Results

MgS improved formulation homogeneity, fluidity, and reduced agglomeration, while the selected mixing protocol enhanced overall powder performance. The optimized formulations showed preliminary physical stability, although progressive changes in texture, fluidity, agglomeration tendency, and aroma were observed during storage. In vitro antibacterial activity was assay-dependent: no measurable inhibition zones were observed by agar diffusion, whereas serial dilution and viable-count assays showed concentration-dependent reductions in bacterial recovery, including effects associated with the vehicle formulation. No macroscopic or histological signs of dermal irritation were observed in mice. In dogs, the formulations were well tolerated under the evaluated conditions. Microbiological outcomes differed numerically among groups but not significantly; among the EO-containing formulations, SCA showed the most favorable exploratory profile, including culture negativity in 3/8 dogs and the highest proportion of dogs reaching a non-significant bacterial burden.

Discussion

These findings support the feasibility of incorporating C. alba and L. philippiana EOs into starch-based dry shampoo prototypes and provide preliminary evidence of physical stability and dermal tolerability. However, the assay-dependent antibacterial response, alkaline formulation pH, limited batch replication, and exploratory clinical design preclude conclusions regarding clinical efficacy. Further studies should include formulation optimization, quantitative chemical stability assessment, dermal permeation studies, and larger randomized controlled clinical trials.

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oai:figshare.com:article/33442582 2026-10-05T11:25:12Z category_24601 category_27142 category_28846 portal_0 item_type_3 month_year_10_2026
10.6084/m9.figshare.33442582.v1 https://figshare.com/articles/dataset/DentDES_code_synthetic_data_and_results_for_a_factorial_discrete-event_evaluation_of_appointment_spacing_and_readiness-aware_dispatch_in_dental_clinics/33442582 https://ndownloader.figshare.com/files/69655695 https://github.com/makyol/dent-des Akyol, Mehmet Ali Mehmet Ali Akyol 0000-0001-8196-946X Astaraki, Fatemeh Fatemeh Astaraki 0009-0005-3004-2206 <![CDATA[DentDES: code, synthetic data and results for a factorial discrete-event evaluation of appointment spacing and readiness-aware dispatch in dental clinics]]> Dentistry not elsewhere classified Health services and systems not elsewhere classified Modelling and simulation dental operations discrete-event simulation appointment scheduling instrument availability patient flow resource coordination paired experiments healthcare operations synthetic data SimPy 2026-10-05 2026-10-05 Dataset 2026 figshare Code, synthetic input data, archived results and diagnostics for the paper "DentDES: A Factorial Discrete-Event Evaluation of Appointment Spacing and Readiness-Aware Dispatch in Dental Clinics" (ISMSIT 2026).

The Python and SimPy model compares two appointment-spacing rules and two dispatch rules (strict first-come-first-served and readiness-aware dispatch with a bypass bound of two) across four demand levels and three instrument-kit capacities. Each condition has 50 paired replication blocks of 30 clinic days (72,000 clinic-day runs). The archive also contains 36,000 exploratory diagnostic runs, validation scripts and recorded checks.

All inputs are synthetic and no patient data were used. Results describe the model and are not estimates of effects in a real clinic. Code is MIT-licensed. Data, results and documentation are CC BY 4.0. See README.md to reproduce and validate: python validate.py --replay-all.

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oai:figshare.com:article/34069395 2026-10-05T11:23:38Z category_35597 portal_96 item_type_3 month_year_10_2026
10.6084/m9.figshare.34069395.v1 https://figshare.com/articles/dataset/diagnose_anomalies_from_Evolutionary_dynamics_of_a_four-stakeholder_ecosystem_for_misinformation_governance_on_short-video_platforms/34069395 https://ndownloader.figshare.com/files/69655827 10.1098/rsos.261361 Song, Xiaoyu Xiaoyu Song Song, Wenjie Wenjie Song <![CDATA[diagnose_anomalies from Evolutionary dynamics of a four-stakeholder ecosystem for misinformation governance on short-video platforms]]> Modelling and simulation Computer Modelling and Simulation Mathematical Modelling 2026-10-05 2026-10-05 Dataset 2026 The Royal Society
oai:figshare.com:article/34069392 2026-10-05T11:23:38Z category_35597 portal_96 item_type_3 month_year_10_2026
10.6084/m9.figshare.34069392.v1 https://figshare.com/articles/dataset/MATLAB_simulation_source_codes_from_Evolutionary_dynamics_of_a_four-stakeholder_ecosystem_for_misinformation_governance_on_short-video_platforms/34069392 https://ndownloader.figshare.com/files/69655824 10.1098/rsos.261361 Song, Xiaoyu Xiaoyu Song Song, Wenjie Wenjie Song <![CDATA[MATLAB simulation source codes from Evolutionary dynamics of a four-stakeholder ecosystem for misinformation governance on short-video platforms]]> Modelling and simulation Computer Modelling and Simulation Mathematical Modelling 2026-10-05 2026-10-05 Dataset 2026 The Royal Society eyJtZXRhZGF0YVByZWZpeCI6ICJvYWlfZGF0YWNpdGUiLCAidmVyYiI6ICJMaXN0UmVjb3JkcyIsICJvYWlfaGFuZGxlciI6IHRydWUsICJuZWVkc19tZXRhZGF0YSI6IGZhbHNlLCAicGFnZSI6IDIsICJ4Q3Vyc29yIjogIklsc3hOemt4TVRrNU5ERTRNREF3TENBek5EQTJPVE01TWwwaS52N3ZXNjVqdV9NRW5sTjRoYXdNblZKdjVFZjAiLCAiZXhwaXJhdGlvbiI6ICIyMDI2LTEwLTA1IDEyOjMxOjUxIn0=