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oai:figshare.com:article/34074077 2026-10-05T17:56:57Z category_1 category_7 category_12 category_13 category_21 category_734 category_931 category_64 category_133 portal_5 item_type_3 month_year_10_2026

<p>Fold change in total GAL protein abundance at 111 mM galactose (2% [w/v]). Values show the ratio of induced (111 mM galactose) to basal (raffinose) protein levels from Paulo et al. [37], Ramsey et al. [18], and our simplified ODE simulations. Bold values indicate the model result closest to the experimental data.</p> Tianyu Wu (2009116) Marie-Christin Spindler (25317353) Abner T. Apsley (14146362) Emmy Earnest (25317356) Zane R. Thornburg (11169477) Julia Mahamid (10496445) Zaida Luthey-Schulten (227919) Biophysics Medicine Cell Biology Genetics Biotechnology Biological Sciences not elsewhere classified Information Systems not elsewhere classified Cancer Plant Biology ribosomes physically bound physical proximity ), ordinary differential equations modulate regulatory dynamics local reaction rules budding yeast (< derived intracellular architectures saccharomyces cerevisiae </ gal2p abundance occurs including chromosome organization intracellular spatial heterogeneity established galactose switch div >< p intracellular organization galactose switch spatial positions gal2p output gal2 </ subcellular organization transport processes spatially organized results demonstrate resolved models react regardless quantitative gene plasma membrane motivating integration modeled using mixed environment little effect largest decrease integrate experimentally gene expression future whole eukaryotic cells enforces locality endoplasmic reticulum electron microscopy distinct compartments develop spatially biochemical constraints <p>Fold change in total GAL protein abundance at 111 mM galactose (2% [w/v]). Values show the ratio of induced (111 mM galactose) to basal (raffinose) protein levels from Paulo et al. [<a href="http://www.ploscompbiol.org/article/info:doi/10.1371/journal.pcbi.1014811#pcbi.1014811.ref037" target="_blank">37</a>], Ramsey et al. [<a href="http://www.ploscompbiol.org/article/info:doi/10.1371/journal.pcbi.1014811#pcbi.1014811.ref018" target="_blank">18</a>], and our simplified ODE simulations. Bold values indicate the model result closest to the experimental data.</p> 2026-10-05T17:56:32Z Dataset Dataset 10.1371/journal.pcbi.1014811.t003 https://figshare.com/articles/dataset/_p_Fold_change_in_total_GAL_protein_abundance_at_111_mM_galactose_2_w_v_Values_show_the_ratio_of_induced_111_mM_galactose_to_basal_raffinose_protein_levels_from_Paulo_et_al_37_Ramsey_et_al_18_and_our_simplified_ODE_simulations_Bold_values_i/34074077 CC BY 4.0