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          <dc:title>&lt;p&gt;Comparative benchmark in conventional experimental evaluation. For the Nyamabo et al. setting, the mean and standard deviation across the three folds are shown. The best performance is shown in bold. † Results taken from Zitnik et al. [5].&lt;/p&gt;</dc:title>
          <dc:creator>Ruben Jimenez (25317319)</dc:creator>
          <dc:creator>Alberto Paccanaro (27961)</dc:creator>
          <dc:subject>Biochemistry</dc:subject>
          <dc:subject>Pharmacology</dc:subject>
          <dc:subject>Biological Sciences not elsewhere classified</dc:subject>
          <dc:subject>Infectious Diseases</dc:subject>
          <dc:subject>sampled negative examples</dc:subject>
          <dc:subject>realistic experimental settings</dc:subject>
          <dc:subject>data available prior</dc:subject>
          <dc:subject>balanced testing datasets</dc:subject>
          <dc:subject>tested drug combinations</dc:subject>
          <dc:subject>given drug combination</dc:subject>
          <dc:subject>drug combinations pose</dc:subject>
          <dc:subject>evaluations include warm</dc:subject>
          <dc:subject>side effect occurs</dc:subject>
          <dc:subject>drug pairs</dc:subject>
          <dc:subject>drug pair</dc:subject>
          <dc:subject>prospective evaluations</dc:subject>
          <dc:subject>side effects</dc:subject>
          <dc:subject>typically involve</dc:subject>
          <dc:subject>structured set</dc:subject>
          <dc:subject>start scenarios</dc:subject>
          <dc:subject>robust prediction</dc:subject>
          <dc:subject>results indicate</dc:subject>
          <dc:subject>restricted number</dc:subject>
          <dc:subject>major challenge</dc:subject>
          <dc:subject>key contribution</dc:subject>
          <dc:subject>introduce dcse</dc:subject>
          <dc:subject>highly imbalanced</dc:subject>
          <dc:subject>first evaluate</dc:subject>
          <dc:subject>clinical trials</dc:subject>
          <dc:subject>art methods</dc:subject>
          <dc:subject>already known</dc:subject>
          <dc:description>&lt;p&gt;Comparative benchmark in conventional experimental evaluation. For the Nyamabo et al. setting, the mean and standard deviation across the three folds are shown. The best performance is shown in bold. † Results taken from Zitnik et al. [&lt;a href="http://www.ploscompbiol.org/article/info:doi/10.1371/journal.pcbi.1013619#pcbi.1013619.ref005" target="_blank"&gt;5&lt;/a&gt;].&lt;/p&gt;</dc:description>
          <dc:date>2026-10-05T17:54:30Z</dc:date>
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          <dc:identifier>10.1371/journal.pcbi.1013619.t001</dc:identifier>
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