2026-10-06T11:58:57Z
https://api.figshare.com/v2/oai
oai:figshare.com:article/34073781
2026-10-05T17:53:00Z
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month_year_10_2026
<p>Pharmacodynamic parameters of drug action as calculated from the corresponding heat flow curves with <i>T. b. rhodesiense</i> STIB900 (Fig 6). Drug concentrations are given in multiples of the respective IC50 for ease of reference to published data [9, 26].</p>
Monica Cal (1637389)
Sonja Keller (25317282)
Romina Rocchetti (448977)
Stéphanie Braillard (23758820)
Jean-Robert Ioset (115415)
Pascal Mäser (87895)
Marcel Kaiser (41510)
Physical Sciences not elsewhere classified
Medicine
Molecular Biology
Pharmacology
Environmental Sciences not elsewhere classified
Ecology
Biological Sciences not elsewhere classified
Cancer
Infectious Diseases
Virology
tsetse fly vectors
resistant field isolate
fatal unless treated
exhibits irreversible cidality
dose oral cure
div >< p
human african trypanosomiasis
trypanosoma brucei </
acoziborole also needs
brucei </
human body
african trypanosomes
rhodesiense </
r </
gambiense </
g </
≥ 4
trypanocidal action
tropical africa
therefore conclude
sleeping sickness
rural areas
preclinical dossier
infectious diseases
historic low
high activity
former accounting
focal prevalence
faster acting
elusive disease
efficacy profiling
depth evaluation
clinical development
bloodstream forms
6 μg
3 μm
15 h
<p>Pharmacodynamic parameters of drug action as calculated from the corresponding heat flow curves with <i>T. b. rhodesiense</i> STIB900 (<a href="http://www.plosntds.org/article/info:doi/10.1371/journal.pntd.0014762#pntd.0014762.g006" target="_blank">Fig 6</a>). Drug concentrations are given in multiples of the respective IC50 for ease of reference to published data [<a href="http://www.plosntds.org/article/info:doi/10.1371/journal.pntd.0014762#pntd.0014762.ref009" target="_blank">9</a>, <a href="http://www.plosntds.org/article/info:doi/10.1371/journal.pntd.0014762#pntd.0014762.ref026" target="_blank">26</a>].</p>
2026-10-05T17:52:49Z
Dataset
Dataset
10.1371/journal.pntd.0014762.t004
https://figshare.com/articles/dataset/_p_Pharmacodynamic_parameters_of_drug_action_as_calculated_from_the_corresponding_heat_flow_curves_with_i_T_b_rhodesiense_i_STIB900_Fig_6_Drug_concentrations_are_given_in_multiples_of_the_respective_IC50_for_ease_of_reference_to_published_d/34073781
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