2026-10-14T14:37:48Z
https://api.figshare.com/v2/oai
oai:figshare.com:article/34073702
2026-10-05T17:50:42Z
category_4
category_146
category_8
category_12
category_19
category_873
category_46
category_734
portal_5
item_type_3
month_year_10_2026
<p>Cytotoxicity (CC<sub>50</sub>), anti-<i>Cryptosporidium</i> activity (IC<sub>50</sub>), and selectivity indices (SI) of NSC158011 and its derivatives against HCT-8 cells.</p>
Chang Xu (102022)
Yaru Ji (9206882)
Qiang Sha (1555231)
Kun Li (277035)
Biochemistry
Space Science
Microbiology
Cell Biology
Pharmacology
Chemical Sciences not elsewhere classified
Immunology
Biological Sciences not elsewhere classified
γ knockout mouse
vitro examination found
systematic structural optimization
regulated key metabolites
inflammatory protein caspase
including isocitric acid
exhibiting reduced toxicity
ethane thioamide ),
div >< p
2 -( phenylthiol
treatment significantly restored
two derivatives identified
cryptosporidium parvum </
parvum </
compound treatment
440 derivatives
29 derivatives
vivo studies
upregulated expression
potential relevance
parasitic infections
parasitic effects
novel inhibitors
native animals
model animals
livestock production
ldh compared
investigations revealed
gut microbiota
expression level
energy metabolism
cryptosporidiosis agents
chemical synthesis
beneficial flora
<p>Cytotoxicity (CC<sub>50</sub>), anti-<i>Cryptosporidium</i> activity (IC<sub>50</sub>), and selectivity indices (SI) of NSC158011 and its derivatives against HCT-8 cells.</p>
2026-10-05T17:58:22Z
Dataset
Dataset
10.1371/journal.pntd.0014742.t001
https://figshare.com/articles/dataset/_p_Cytotoxicity_CC_sub_50_sub_anti-_i_Cryptosporidium_i_activity_IC_sub_50_sub_and_selectivity_indices_SI_of_NSC158011_and_its_derivatives_against_HCT-8_cells_p_/34073702
CC BY 4.0