2026-10-06T04:05:01Z https://api.figshare.com/v2/oai

oai:figshare.com:article/34072046 2026-10-05T17:32:00Z category_734 portal_5 item_type_3 month_year_10_2026

<p>eSign data extraction.</p> Tracey J. Brown (24900799) Natalie An Qi Tham (25316900) Felix Naughton (3554933) Henry Goodfellow (24885973) Louise Hull (9254840) Helena Jopling (25316903) Helen M. Parretti (7239872) Alex T. Ramsey (4865602) Adam P. Wagner (9166166) Zarnie Khadjesari (227946) Biological Sciences not elsewhere classified popular communication channel improve service reach health economic analysis field would benefit existing technical systems promote &# 8216 improved &# 8216 risk existing patient novel programme theory xlink "> uptake narrative evidence syntheses implement electronic signposting ensuring electronic signposting electronic signposting works 57 individual context cancer prevention interventions electronic signposting &# 8217 patient characteristics reduce cancer prevent cancer cancer disparities based interventions usa contexts united states term outcomes quality based qualitative insight provider relationships protocol registration outcome configurations organisational priorities increasingly utilised increasing optimism healthcare setting grey literature good fit evolving standards establishing compatibility contributed information amed databases also key aid development <div><p>Uptake of evidence-based interventions that prevent cancer is very low. Electronic signposting using digital messages sent via electronic healthcare systems is increasingly utilised to improve service reach and uptake. However, theory for optimising the implementation of electronic signposting to cancer prevention interventions is lacking. We sought to generate a novel programme theory to illuminate what type of electronic signposting works, for whom and in what circumstances. A realist review, informed by Realist And Meta-narrative Evidence Syntheses: Evolving Standards (RAMESES I), was conducted. Medline, EMBASE, CINAHL, Scopus, PsycINFO, ERIC and AMED databases, and grey literature were searched. Studies that contributed information on context and mechanisms of action for electronic signposting to cancer prevention interventions for adults in any healthcare setting were included. Studies were assessed for quality based on relevance, richness and rigour. Realist synthesis and input from stakeholders, including patients, was used to aid development of our novel programme theory. Thirty studies were included, 26 of which were conducted in the United States. 57 individual context-mechanism-outcome configurations were identified. For patients, memorable messages using wording tailored to patient characteristics, and use of a popular communication channel (e.g., SMS text) improved ‘buy-in’ and usability. For providers, a good fit with organisational priorities, workflow, and establishing compatibility with existing technical systems was important. Increasing optimism of technology and ensuring electronic signposting did not risk existing patient-provider relationships were also key to success. To reduce cancer and cancer disparities, policymakers and providers need to implement electronic signposting in ways that promote ‘buy-in’, ensure perceived usability, and nurture positive attitudes towards technology. The field would benefit from further qualitative insight, health economic analysis, exploration of equity and long-term outcomes, and research in non-USA contexts. Protocol registration: PROSPERO [CRD42024586907].</p></div> 2026-10-05T17:31:56Z Dataset Dataset 10.1371/journal.pdig.0001770.s003 https://figshare.com/articles/dataset/_p_eSign_data_extraction_p_/34072046 CC BY 4.0