2026-10-06T10:37:11Z https://api.figshare.com/v2/oai

oai:figshare.com:article/34070958 2026-10-05T16:53:49Z category_24718 item_type_3 month_year_10_2026

TRPV1 Is Critical for Generating Immediate Apneic Response to Fentanyl Xiuping Gao (23885425) JIANGUO ZHUANG (18057157) Shan Shi (23885428) Fadi Xu (22538365) Systems physiology TRPV1-MOR interaction, bradypnea, analgesia, colocalization of TRPV1 and MOR, vagal sensory afferents <p dir="ltr">The Dataset from our study reveal that the apneic response is facilitated by systemic activation of TRPV1, but nearly blocked by antagonism of these receptors. Particularly, MORs and TRPV1 are co-expressed in vagal sensory afferents and their local interaction play a key role in generating the fentanyl-induced apnea.</p> 2026-10-05T16:53:49Z Dataset Dataset 10.6084/m9.figshare.34070958.v1 https://figshare.com/articles/dataset/TRPV1_Is_Critical_for_Generating_Immediate_Apneic_Response_to_Fentanyl/34070958 CC BY 4.0