2026-10-12T03:21:35Z https://api.figshare.com/v2/oai

oai:figshare.com:article/34056708 2026-10-02T13:22:37Z category_696 portal_316 item_type_3 month_year_10_2026

Table 4_Polysaccharides from Radix Hedysari exhibited preventive effects against DSS-induced ulcerative colitis in C57BL/6 mice.docx Lujie Ma (9421401) Yu Han (251741) Xueqin Zhao (3763675) Yixiu Niu (25302423) Yuxin Xie (4527673) Yating Pan (7954772) Yaxin Zheng (754833) Zhiyuan Xue (2301253) Genetic Immunology 16S rRNA sequencing Hedysarum inflammation intestinal microbiota polysaccharides ulcerative colitis <p>Hedysarum polysaccharide (HPS), the major bioactive constituent of Radix Hedysari, possesses anti-inflammatory activity; however, few studies have explored its application for ulcerative colitis (UC). In this study, HPS-80 was extracted using combined complex-enzyme hydrolysis and ultrasonication. We further evaluated its preventive effects and underlying mechanisms in a dextran sulfate sodium (DSS)-induced UC model in C57BL/6 mice. Results showed HPS-80 significantly improved DSS-induced UC symptoms (weight loss, hematochezia, colon shortening) and reduced Disease Activity Index (DAI). Mechanistically, it inhibited pro-inflammatory factors Tumor Necrosis Factor-alpha(TNF-α),Interleukin-6, (IL-6), alleviated oxidative stress, upregulated tight junction proteins occludin, claudin-1(ZO-1), and modulated intestinal microbiota (suppressed harmful bacteria like Bacteroidota, enriched beneficial ones like Firmicutes and Akkermansia). Conclusion: HPS-80 exerts protective effects against UC via anti-inflammatory, antioxidant and gut-microbiota-regulating capacities. It is a promising candidate agent for UC prevention.</p> 2026-10-02T13:22:37Z Dataset Dataset 10.3389/fimmu.2026.1944924.s001 https://figshare.com/articles/dataset/Table_4_Polysaccharides_from_Radix_Hedysari_exhibited_preventive_effects_against_DSS-induced_ulcerative_colitis_in_C57BL_6_mice_docx/34056708 CC BY 4.0