2026-10-07T03:45:03Z https://api.figshare.com/v2/oai

oai:figshare.com:article/34056258 2026-10-02T10:59:43Z category_658 portal_316 item_type_3 month_year_10_2026

Table 1_Microglia as candidate links between hormonal signals and neuronal circuits in polycystic ovary syndrome: evidence gaps and a research agenda.docx Hongtao Li (85789) Tong Yin (3576917) Yichen Wang (358419) Yixuan Wang (643708) Xiaoyuan Lin (6558212) Xinyan Jia (431900) Wei Yi (321782) Han Yang (704814) Cell Metabolism androgen excess evidence synthesis gonadotropin-releasing hormone hypothalamus microglia neuroendocrinology neuroinflammation polycystic ovary syndrome <p>Polycystic ovary syndrome (PCOS) combines reproductive endocrine dysfunction with metabolic, autonomic, and neurobehavioral phenotypes, yet the contribution of brain microglia remains uncertain. We conducted a structured narrative review that separates human PCOS evidence, PCOS-like animal findings, PCOS-related cellular observations, and non-PCOS mechanistic bridges. Only three heterogeneous PCOS-like studies directly assessed microglial outcomes, and none established a conserved microglial state, microglial necessity, a complete hormone–microglia–neuron causal chain, or human relevance. We therefore propose the PCOS Neuroimmune-Endocrine Triangular Network (PNETN), a falsifiable framework linking endocrine and metabolic signals, context-dependent microglial states, and neuronal circuits regulating GnRH/KNDy activity, luteinizing-hormone dynamics, ovulation, metabolism, autonomic function, and behavior. The framework defines criteria for causal promotion, including cell identity, regional specificity, temporal precedence, selective perturbation, rescue, orthogonal functional readouts, and independent replication. Microglia should currently be regarded as candidate contributors, not established clinical targets.</p> 2026-10-02T10:59:43Z Dataset Dataset 10.3389/fendo.2026.1952469.s001 https://figshare.com/articles/dataset/Table_1_Microglia_as_candidate_links_between_hormonal_signals_and_neuronal_circuits_in_polycystic_ovary_syndrome_evidence_gaps_and_a_research_agenda_docx/34056258 CC BY 4.0