2026-10-10T11:01:11Z https://api.figshare.com/v2/oai

oai:figshare.com:article/34054764 2026-10-02T05:41:39Z category_696 portal_316 item_type_3 month_year_10_2026

Data Sheet 2_CircUGP2 inhibits tumor progression via PI3K/AKT/mTOR signaling through sponging miR-137-3p and interacting with UPF1 in hepatocellular carcinoma.xlsx Longfei Xie (1593961) Suxin Li (3532721) Huahu Guo (6874007) Wenhui Zhang (425538) Mengjie Shang (25162767) Bailin Cheng (25162770) Dingyang Li (14261996) Luhao Li (14261993) Zhaochen Liu (14261987) Lin Li (28817) Liang Bao (214906) Kaiwei Tian (25162773) Chengxuan Li (11581152) Xiaowei Dang (14262005) Genetic Immunology circUGP2 hepatocellular carcinoma KLF4 PI3K/Akt/mTOR pathway UPF1 Background<p>Circular RNA (circRNA) has been shown to have a pivotal role in the initiation and evolution of multiple tumors, but its function in hepatocellular carcinoma (HCC) requires further elucidation.</p>Methods<p>circUGP2 (hsa_circ_0001020) was identified in the GEO database by HCC circRNA microarray. Subsequently, an assessment was conducted to determine the biological effects of circUGP2, employing a series of analytical methods, including CCK8, EdU, colony formation, transwell, scratch assays, and in vivo experimentation. To explore the functions of circUGP2 as a sponge, including RNA pull-down, microRNA-seq, fluorescence in situ hybridization (FISH), RNA immunoprecipitation (RIP), and luciferase reporter assays were employed. Mass spectrometry (MS), RIP, and co-inmunoprecipitation (Co-IP) were employed to examine the interaction between cirrcUGP2 and up-frameshift protein 1 (UPF1).</p>Results<p>circUGP2 was downregulated in HCC tissues and cells, which inhibited the growth and spread of HCC in vitro and in vivo. In the mechanisms, circUGP2 has the capacity to modulate KLF4 by sponging miR-137-3p, thereby suppressing HCC growth and migration. In addition, circUGP2 could combine with UPF1 and facilitate an interplay between UPF1 and AKT, influencing tumor progression in HCC via inactivation of the PI3K/AKT signaling pathway.</p>Conclusion<p>circUGP2 has a crucial function in HCC development by modulating the miR-137-3p/KLF4 axis to inactivate the PI3K/AKT/mTOR pathway and by interacting with UPF1. The findings indicate the potential of circUGP2 as a novel biomarker and target for HCC.</p> 2026-10-02T05:41:39Z Dataset Dataset 10.3389/fimmu.2026.1926747.s002 https://figshare.com/articles/dataset/Data_Sheet_2_CircUGP2_inhibits_tumor_progression_via_PI3K_AKT_mTOR_signaling_through_sponging_miR-137-3p_and_interacting_with_UPF1_in_hepatocellular_carcinoma_xlsx/34054764 CC BY 4.0