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Additional file 2 of Alzheimer’s disease polygenic risk, APOE ε4 dose, and accelerometer-derived circadian rest–activity rhythms in relation to incident dementia and Alzheimer’s disease in UK Biobank: a prospective cohort study Simin Yang (6079499) Xiong Xiao (1516009) Yuqian Yang (5561879) Yinqian Cai (25162200) Yuxi Zou (504653) Yanping Tang (191977) Huihan Ma (11578373) Zelin Lai (8976176) Medicine Cell Biology Genetics Neuroscience Biotechnology Developmental Biology Cancer Mental Health Hematology Alzheimer’s disease Polygenic risk score APOE Accelerometry Circadian rhythm Incident dementia Additional file 2: Supplementary Tables S1–S9. Description: Multiple-testing results, genotype-category sensitivity analyses, ancestry restriction analyses, diagnostics, full Cox outputs, ICD-10 code lists, incident interaction analyses, mutual-adjustment sensitivity analyses, and the comparison of accelerometry-included versus excluded participants referenced in the main text. Table S1. Multiple-testing results for IS/IV. Raw p values with Bonferroni and BH-FDR corrections across 8 prespecified tests. Table S2. APOE genotype-category sensitivity analysis. Cross-sectional models comparing ε2/4, ε3/4, and ε4/4 groups with non-carriers, plus analyses excluding ε2/4. Table S3. European-only cross-sectional models. Regression outputs restricted to ancestry_group = 1. Table S4. IS/IV model diagnostics. Dropped covariates and diagnostics under QC ≥ 240 30-min bins. Table S5. Full Cox model outputs. Fully adjusted Cox outputs for incident dementia and incident Alzheimer’s disease. Table S6. ICD-10 code lists. Codes used for dementia and Alzheimer’s disease definitions (broad and strict). Table S7. Incident interaction analyses. Fully adjusted Cox models for RA × AD-PRS and RA × APOE ε4 dose in incident dementia and broad Alzheimer’s disease; all interaction p values are nominal. Table S8. Mutual-adjustment sensitivity analysis. Cross-sectional models including both AD-PRS and APOE ε4 dose for RA and phase-timing outcomes. Table S9. Accelerometry subcohort comparison. Baseline comparison of participants included in versus excluded from the accelerometry analytic cohort, used for the inverse-probability-weighted selection analysis. 2026-06-01T05:00:00Z Dataset Dataset 10.6084/m9.figshare.34054083.v1 https://figshare.com/articles/dataset/Additional_file_2_of_Alzheimer_s_disease_polygenic_risk_APOE_4_dose_and_accelerometer-derived_circadian_rest_activity_rhythms_in_relation_to_incident_dementia_and_Alzheimer_s_disease_in_UK_Biobank_a_prospective_cohort_study/34054083 CC BY