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oai:figshare.com:article/34053870 2026-10-02T04:40:26Z category_388 portal_316 item_type_3 month_year_10_2026

Table 1_Age-stratified gradients of colorectal neoplasia and an exploratory endoscopic red-flag composite in a lesion-confirmed screening colonoscopy cohort.docx Lina Du (199940) Jingzhi Su (25161876) Jihua Dai (25161879) Peipei Pu (25161882) Li Meng (136180) Feiyan Zhao (9566354) Lili Pang (9026114) Sizhu Li (9454094) Yanxia Zhang (483434) Xin Rong (1658305) Huihong Zhai (3746155) Sufang Shen (25161888) Oncology and Carcinogenesis not elsewhere classified age stratification colonoscopy colorectal neoplasia exploratory analysis Helicobacter pylori red-flag composite 9Objective<p>To characterise age-related gradients in colorectal lesion severity and prespecified high-risk endoscopic features in a lesion-confirmed screening colonoscopy cohort and to evaluate an investigator-defined red-flag composite as an exploratory marker of advanced pathology. Helicobacter pylori was assessed as a secondary exposure.</p>Methods<p>This retrospective cohort included 291 participants with histologically confirmed lesions in four age groups (36–45, 46–55, 56–65 and 66–72 years). Logistic regression evaluated predictors of advanced neoplasia (high-grade dysplasia [HGD] or adenocarcinoma); adenocarcinoma-only and age × H. pylori interaction analyses were exploratory because events were sparse.</p>Results<p>With advancing age, body mass index, H. pylori positivity, adenoma, sessile serrated lesions, HGD, adenocarcinoma and high-risk endoscopic features increased, whereas hyperplastic polyps decreased (all P < 0.05). Age (per 10 years), male sex, H. pylori positivity, lesion size ≥10 mm, proximal location and JNET 2B/3 pattern were independently associated with advanced neoplasia. Red-flag positivity (≥2 of four features) increased from 5.2% to 32.7% and enriched for adenocarcinoma, although positive predictive values were imprecise and non-monotonic.</p>Conclusions<p>Colorectal lesion severity and high-risk endoscopic features showed an age-related gradient. The red-flag composite is an exploratory descriptive construct, not a validated predictive score. H. pylori findings, especially interaction analyses, are hypothesis-generating and require prospective validation.</p> 2026-10-02T04:40:26Z Dataset Dataset 10.3389/fonc.2026.1842525.s001 https://figshare.com/articles/dataset/Table_1_Age-stratified_gradients_of_colorectal_neoplasia_and_an_exploratory_endoscopic_red-flag_composite_in_a_lesion-confirmed_screening_colonoscopy_cohort_docx/34053870 CC BY 4.0