2026-10-12T04:47:27Z https://api.figshare.com/v2/oai

oai:figshare.com:article/34053626 2026-10-02T04:37:44Z category_13 portal_81 item_type_3 month_year_10_2026

Additional file 2 of ZNF292 mutations impair RNA and protein biosynthesis defining an adverse prognostic subset in early-stage chronic lymphocytic leukemia Alberto Rodríguez-Sánchez (25161482) María Alonso-Gago (25161485) Claudia Pérez-Carretero (25161488) Luis A. Corchete-Sánchez (25161491) Cristina Miguel-García (25161494) Sandra Santos-Minguez (25161497) Ángela Villaverde-Ramiro (25161500) José Antonio Queizán-Hernandez (25161503) Araceli Rubio (25161506) Rocío Benito-Sánchez (25161509) Federico Lo Schiavo (18227313) Martina Ghetti (5431652) Giorgia Simonetti (3404063) Ana E. Rodríguez-Vicente (25161512) Jesús M. Hernández-Rivas (8902559) Miguel Quijada-Álamo (3919850) Genetics protein biosynthesis defining primary patient samples median 93 vs median 25 vs isogenic cellular models inferior overall survival independent prognostic factor drug response assays dna damage accumulation chronic lymphocytic leukemia adverse prognostic subset 3 %- 6 primary cll samples cll cellular models cll ), occurring specific clinical relevance prevalent znf292 variants independent prognostic role transcriptomic analyses revealed results znf292 mutations stage cll transcriptomic data clinical significance znf292 mutations znf292 alterations vitro sensitivity stage cases shorter time sequencing data risk subgroup recurrently detected integrating rna genome editing generation sequencing functional validation functional implications first treatment edited cells disease progression 6q deletions 52 months 148 months 004 ). Supplementary Material 2 2026-10-01T05:00:00Z Dataset Dataset 10.6084/m9.figshare.34053626.v1 https://figshare.com/articles/dataset/Additional_file_2_of_ZNF292_mutations_impair_RNA_and_protein_biosynthesis_defining_an_adverse_prognostic_subset_in_early-stage_chronic_lymphocytic_leukemia/34053626 CC BY