2026-10-14T03:55:20Z https://api.figshare.com/v2/oai

oai:figshare.com:article/34053378 2026-10-02T04:36:21Z category_388 portal_316 item_type_3 month_year_10_2026

Table 1_Stage IA undifferentiated uterine sarcoma with SMARCA4 and SMARCA2 co-deficiency: a case report.docx Rong Ji (1496803) Xialin Chen (11861460) Juan Lang (17022510) Zhongkui Xiong (24300518) Oncology and Carcinogenesis not elsewhere classified co-deficiency disease-free survival SMARCA2 SMARCA4 undifferentiated uterine sarcoma <p>Uterine sarcomas represent a rare and heterogeneous group of malignancies whose management remains clinically challenging. They account for approximately 3%–5% of all uterine malignancies. Undifferentiated uterine sarcoma (UUS) is a subtype of uterine sarcomas. SMARCA4 is a tumor suppressor gene that is aberrantly altered in approximately 5%–7% of human malignancies. SMARCA4-deficient UUS is a highly aggressive, undifferentiated mesenchymal neoplasm associated with a median overall survival (OS) of 7 months. During tumorigenesis, loss of function of either SMARCA4 or SMARCA2 is frequently observed; however, concurrent loss of both genes has been reported to be synthetically lethal and is therefore considered unexpected. In this case report, a 52-year-old Chinese woman with early-stage UUS and SMARCA4 and SMARCA2 co-deficiency underwent surgical resection followed by adjuvant chemotherapy and achieved a disease-free survival (DFS) of 32 months. This case suggests that patients with UUS harboring SMARCA4 and SMARCA2 co-deficiency may derive a survival benefit from early diagnosis and surgical resection. However, owing to the extreme rarity of UUS with co-deficiency of SMARCA4 and SMARCA2, conducting a high-level phase III randomized controlled trial to validate this observation remains impractical.</p> 2026-10-02T04:36:21Z Dataset Dataset 10.3389/fonc.2026.1939651.s001 https://figshare.com/articles/dataset/Table_1_Stage_IA_undifferentiated_uterine_sarcoma_with_SMARCA4_and_SMARCA2_co-deficiency_a_case_report_docx/34053378 CC BY 4.0