2026-10-09T23:00:37Z
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2026-10-01T18:00:18Z
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<p>(A-B) IgG secreting rate from (A) total IgG-SC or from (B) IgG-SC binding to sE and/or sE-dimer of DENV1 or DENV2 in PBMCs from indicated hospitalized dengue patients and subclinical cases at day 5 post RT-qPCR confirmed DENV infection, corresponding to day 7–8 after onset of symptoms.</p>
Amandine Trouchet (25157966)
Sokchea Lay (9857198)
Matteo Broketa (19690885)
Pablo Canales-Herrerias (25157969)
Angga Perima (19690879)
Bruno Iannascoli (17818357)
Sotheary Sann (12039614)
Borita Heng (25157972)
Sowath Ly (160224)
Veasna Duong (106893)
Gaël A. Millot (25157975)
Laura Walker (4841532)
Patrick England (28458)
Giovanna Barba-Spaeth (12066108)
Tineke Cantaert (68002)
Pierre Bruhns (5334050)
Medicine
Microbiology
Neuroscience
Biotechnology
Chemical Sciences not elsewhere classified
Immunology
Cancer
Infectious Diseases
Virology
Computational Biology
monomers &# 8212
monoclonal level contributes
fold lower compared
cambodian pediatric cohort
based microfluidic imaging
developing antibody response
broadly reactive antigen
dengue severity may
secreting cells relative
profiled single igg
300 single igg
secreting cells
specific antibody
reactive antibodies
hospitalized dengue
virion surface
using droplet
threatening illness
sufficient numbers
similar frequencies
serotype cross
secreted antibodies
qualitative differences
outcomes ranging
inefficient generation
forms homodimers
findings suggest
detected exclusively
acute denv1
<p>Horizontal bars represent median and interquartile range. Each dot represents one IgG-SC. p values were calculated using two-by-two contrast comparisons after linear modelling. *, p ≤ 0.05; **, p ≤ 0.01; ***, p ≤ 0.001; ****, p ≤ 0.0001. Of note, non-significant differences are not represented.</p> <p>(TIFF)</p>
2026-10-01T17:54:57Z
Image
Figure
10.1371/journal.ppat.1014552.s002
https://figshare.com/articles/figure/_p_A-B_IgG_secreting_rate_from_A_total_IgG-SC_or_from_B_IgG-SC_binding_to_sE_and_or_sE-dimer_of_DENV1_or_DENV2_in_PBMCs_from_indicated_hospitalized_dengue_patients_and_subclinical_cases_at_day_5_post_RT-qPCR_confirmed_DENV_infection_corresp/34050084
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