2026-10-12T09:45:41Z
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2026-10-01T17:51:38Z
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<p>Long-range inhibitory connections are less functional.</p>
Felix Benjamin Kern (17145132)
Takahisa Date (25158079)
Zenas C. Chao (17145135)
Medicine
Neuroscience
Biotechnology
Biological Sciences not elsewhere classified
Developmental Biology
Mental Health
Infectious Diseases
supercritical behavior compared
spike pairs outside
related systems organized
optimal information processing
network &# 8217
stochastic intrinsic activity
resulting network activity
spiking neural networks
operate near criticality
dimensional spiking networks
allow synaptic weights
inhibitory connectivity influences
range inhibitory synapses
development towards criticality
range synapses
synaptic weights
inhibitory connectivity
synaptic delays
inhibitory plasticity
full connectivity
weaker long
systematically constrain
storage capabilities
spatially distributed
spatial organization
spatial constraints
similar number
signal timing
potentiation window
low level
key determinant
dynamical development
development due
critical point
<p><b>(A)</b> Slopes of linear fits relating to average inhibitory weights in each slice of . See <a href="http://www.ploscompbiol.org/article/info:doi/10.1371/journal.pcbi.1014798#pcbi.1014798.g006" target="_blank">Fig 6</a> for an explanation of the slices and <a href="http://www.ploscompbiol.org/article/info:doi/10.1371/journal.pcbi.1014798#pcbi.1014798.s005" target="_blank">S5</a> – <a href="http://www.ploscompbiol.org/article/info:doi/10.1371/journal.pcbi.1014798#pcbi.1014798.s008" target="_blank">S8 Figs</a> for scatter plots of each slice. Orange color indicates significant linear correlations (Bonferroni-corrected p < 0.05). <b>(B)</b> Slopes of linear fits relating to average excitatory weights in each slice of . <b>(C)</b> Relationship between inhibitory weight and synaptic distance within networks. The weight of inhibitory synapses (mean across development) is plotted against the distance between the corresponding neurons in a representative sample network ( mm, ; ). The orange line represents the linear fit. <b>(D)</b> Top: Distributions of Pearson’s <i>r</i> of this correlation within networks (i.e., between weight and distance of inhibitory synapses). Boxes show quartiles, with whiskers extending to points within 1.5 times the interquartile range. Boxes are clustered by the (categorical) value of and color-coded by . Bottom: Fraction of networks showing significant Pearson’s correlation for the - parameter space. Significance was assessed with a two-tailed t-test and Bonferroni correction at <i>p</i> < 0.05.</p>
2026-10-01T18:04:22Z
Image
Figure
10.1371/journal.pcbi.1014798.g007
https://figshare.com/articles/figure/_p_Long-range_inhibitory_connections_are_less_functional_p_/34049635
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