2026-10-14T10:15:02Z
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2026-10-01T17:46:54Z
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<p>Location of G574 at the CNBHD-CNBHD interface of the EGL-2/EAG channel.</p>
Xinyu Huang (679541)
Sudharsan Kannan (25158064)
Gail A. Robertson (15007385)
Han Wang (254423)
Biochemistry
Cell Biology
Genetics
Molecular Biology
Neuroscience
Physiology
Cancer
Hematology
regulate neuronal excitability
promoting neuron ala
influence channel gating
hallmark cyclic nucleotide
genetic analysis demonstrated
forward genetics reveals
electrophysiological analysis showed
dependent channel activation
calcium imaging showed
binding homology domains
adjacent channel subunits
accelerates activation kinetics
subfamily kcnh channels
conserved gating mechanism
important sleep regulator
findings identify egl
div >< p
caenorhabditis elegans </
similarly suppresses sleep
2 functions cell
elegans </
suppresses sleep
kcnh voltage
vivo </
conserved cnbhd
central sleep
shifts voltage
second substitution
negative potentials
intrinsic ligand
g574r ),
function effects
corresponding residue
<p>A rotating view of structural models of the PAS domains and CNBHDs within the EGL-2/EAG tetramer channel is followed by a magnified view of the residue G574 at the CNBHD-CNBHD interface. PAS domains are shown in orange, CNBHDs in cyan, and G574 in red. The structure was predicted using AlphaFold3. Other domains of EGL-2 are omitted for clarity.</p> <p>(MP4)</p>
2026-10-01T17:54:06Z
Dataset
Media
10.1371/journal.pgen.1012255.s004
https://figshare.com/articles/media/_p_Location_of_G574_at_the_CNBHD-CNBHD_interface_of_the_EGL-2_EAG_channel_p_/34049509
CC BY 4.0