2026-10-12T22:22:16Z https://api.figshare.com/v2/oai

oai:figshare.com:article/34049392 2026-10-01T17:46:41Z category_915 category_8 category_13 category_272 category_39 category_734 category_64 category_132 portal_5 item_type_1 month_year_10_2026

Principal component analysis (PCA) of 278,855 unlinked SNVs. Egie E. Enabuele (25158001) Roy N. Platt II (13783184) Ehizogie E. Adeyemi (25158004) Martins S. O. Aisien (25158007) Oluwaremilekun G. Ajakaye (4243018) Mahmud U. Ali (25158010) Ebube C. Amaechi (25158013) Tolulope E. Atalabi (25158016) Timothy Auta (25158019) Oluwaseun B. Awosolu (25158022) Adamu G. Dagona (25158025) Omoyemwen Edo-Taiwo (25158028) Chika P. Ejikeugwu (25158031) Christopher Igbeneghu (25158034) Victor S. Njom (10928747) Marian Onwude-Agbugui (25158037) Mary-Kate N. Orji (25158040) Funso O. P. Oyinloye (25158043) Esther Oyemade (25158046) Habibat J. Ozemoka (25158049) Christopher R. Pam (25158052) Uchenna I. Ugah (25158055) Jenna M. Hulke (25158058) Grace A. Arya (25158061) Timothy J. C. Anderson (7548590) Physical Sciences not elsewhere classified Microbiology Genetics Environmental Sciences not elsewhere classified Ecology Biological Sciences not elsewhere classified Cancer Infectious Diseases tight cluster regardless internal transcribed spacer genome sequencing revealed approach requires reinterpretation also genome sequenced 14 nigerian locations schistosomes containing 50 early generation hybrids documenting zoonotic infection detecting zoonotic infection div >< p suggesting zoonotic infection 132 parasites isolated schistosoma haematobium </ livestock schistosome markers bovis cox1 </ zoonotic infection livestock schistosomes schistosoma </ zoonotic infections schistosome epidemiology recent hybrids bovis </ haematobium </ cox1 </ livestock parasites livestock counterparts curassoni </ cox </ wide ancestry well differentiated used approaches typically inferred southern nigeria results demonstrate northern nigeria modest levels misleading inference low levels human urine The samples differentiated in genotypic space, as visualized with PCA. Each species forms a distinct cluster separated along PC1 and PC2. Known hybrid individuals fall intermediate to the parental species clusters, including the laboratory-generated F1 S. haematobium × S. bovis hybrid [<a href="http://www.plospathogens.org/article/info:doi/10.1371/journal.ppat.1014625#ppat.1014625.ref067" target="_blank">67</a>] and natural S. curassoni × S. bovis hybrids [<a href="http://www.plospathogens.org/article/info:doi/10.1371/journal.ppat.1014625#ppat.1014625.ref019" target="_blank">19</a>]. Samples are colored according to their ITS genotypes and marker shapes are used to identify the mitotype. All individuals collected from cattle presented homozygous S. bovis ITS alleles. Miracidia from humans presented S. haematobium, S. curassoni, or heterozygous S. haematobium/S. curassoni ITS alleles. None of the parasites with heterozygous S. haematobium/S. curassoni ITS alleles appear intermediate between S. haematobium and S. curassoni, as would be expected for early-generation hybrids. The three sub-plots show that all samples collected in humans form a single genetic cluster regardless of whether they carry (b) SHxSH, (c) SCxSC and (d) SHxSC, ITS alleles. 2026-10-01T17:46:27Z Image Figure 10.1371/journal.ppat.1014625.g003 https://figshare.com/articles/figure/_p_Principal_component_analysis_PCA_of_278_855_unlinked_SNVs_p_/34049392 CC BY 4.0