2026-10-13T19:09:36Z https://api.figshare.com/v2/oai

oai:figshare.com:article/34049252 2026-10-01T17:46:15Z category_4 category_8 category_12 category_15 category_16 category_39 category_46 category_734 category_132 category_134 portal_5 item_type_1 month_year_10_2026

<p>Weight and kidney function markers in MRL/lpr mice injected with curli.</p> Kaitlyn Grando (12527650) Molly Elkins (9980979) Lauren Nicastro (25157996) Shingo Bessho (13257073) Sophia Olubajo (24393496) Anita Kowal (25157999) Vincent Tam (2583448) Roberto Caricchio (18920) David Pisetsky (5618543) Gregg J. Silverman (7949903) Çagla Tükel (45788) Biochemistry Microbiology Cell Biology Neuroscience Physiology Ecology Immunology Biological Sciences not elsewhere classified Infectious Diseases Virology specific elisa confirmed significantly affect proteinuria chromatin autoantibody responses div >< p systemic lupus erythematosus demonstrated increased anti f1 mice compared biofilms drive anti f1 mice previously demonstrated autoantibody levels prone mice older mice lpr mice young nzbxw treated controls study uncovers spontaneous disease salmonella </ prone nzbxw prominent feature often marked novel mechanism increasing morbidity either model disease stage disease flares coli </ autoimmune manifestations amyloidogenic protein already high <p>MRL/lpr mice were injected intraperitoneally with curli purified from <i>Salmonella</i> Typhimurium biofilms, or PBS in untreated controls. (<b>A</b>) Mice were weighed weekly 6 hours after each injection; weight gain was graphed relative to starting weight 1 week before first curli injection (Week –1) (N = 10). (<b>B</b>) Protein levels in urine (proteinuria) were assayed by Uristix dipsticks. (<b>C</b>) Blood urea nitrogen (BUN) was measured in serum. Statistics: (<b>A, C</b>) Two-way ANOVA (<b>B</b>) mixed effects analysis with Sidak‘s multiple comparisons, comparisons within the legends indicate overall column factor (*p < 0.05, **p < 0.01).</p> <p>(TIFF)</p> 2026-10-01T17:56:08Z Image Figure 10.1371/journal.ppat.1014666.s005 https://figshare.com/articles/figure/_p_Proteinuria_not_significantly_altered_by_curli_in_MRL_lpr_mice_p_/34049252 CC BY 4.0