2026-10-12T03:01:35Z https://api.figshare.com/v2/oai

oai:figshare.com:article/34049233 2026-10-01T17:44:32Z category_7 category_8 category_21 category_39 category_46 category_64 category_132 category_134 portal_5 item_type_1 month_year_10_2026

<p>Immune responses to SARS-CoV-2 in loiasis exposed individuals.</p> Maximilian Augé Stock (25157980) Dearie Glory Okwu (18592296) Ayong More (18592293) Anna Doralt (25157983) Rodrigue Bikangui (5851262) Ismaël Pierrick Mikelet Boussoukou (25157986) Kirsten Alexandra Eberhardt (7339937) Maren Sandkuhl (25157989) Rella Zoleko Manego (9034322) Ghyslain Mombo-Ngoma (265164) Matthew McCall (3448769) Minka Breloer (78015) Meral Esen (211790) Marylyn Addo (722007) Bertrand Lell (224978) Luzia Veletzky (3831247) Rafiou Adamou (12419233) Maria Sophia Mackroth (3309018) Medicine Microbiology Biotechnology Ecology Immunology Cancer Infectious Diseases Virology subsequent analysis across rapid assessment procedure ogoou &# 233 ngouni &# 233 elevated regulatory cytokines broader immunological effects three groups confirmed specific igg responses loa loa </ infection influences antibody ifn -&# 947 occult participants (< microfilaremic individuals compared 2 </ p loa </ participants (< occult disease immunological assays p </ 192 participants microfilaremic compared γ responses xlink "> without evidence west africa viral antigens substantial morbidity study investigated skewed responses sectional study periurban villages nucleocapsid proteins latter defined including th2 immune modulation identified using findings suggest circulating microfilariae cell responses cell hyporesponsiveness assessed using 90 ). 59 ), <p>Upper panel: comparison of non-microfilaremic (= NM: No sign of active loiasis combined with occult loiasis) versus microfilaremic participants (ML = Microfilaremic loiasis). Lower panel: comparison across three groups (NL = No sign of active loiasis, OL = Occult loiasis, ML = Microfilaremic loiasis). For each panel, Anti-S1-IgG concentrations <b>(a)</b>, Anti-NCP-IgG ratios <b>(b)</b>, Interferon-γ concentrations (c) are shown as individual values. The box shows the median and interquartile range (IQR, 25th–75th percentile). Whiskers extend to the most extreme values not exceeding 1.5 × IQR from the first and third quartiles; outliers beyond these limits are plotted as individual points. Intergroup differences were assessed using non-parametric Wilcoxon-rank-sum test (upper panel) or Kruskal-Wallis with subsequent pairwise post hoc comparisons using false discovery rate (FDR) correction (lower panel) and adjusted for the confounders age and sex. <i>P</i>-values of intergroup comparisons are provided if p < 0.05. * p < 0.05.</p> 2026-10-01T17:55:58Z Image Figure 10.1371/journal.pntd.0014104.g002 https://figshare.com/articles/figure/_p_Immune_responses_to_SARS-CoV-2_in_loiasis_exposed_individuals_p_/34049233 CC BY 4.0