2026-10-11T02:28:40Z https://api.figshare.com/v2/oai

oai:figshare.com:article/34049135 2026-10-01T17:43:00Z category_4 category_12 category_13 category_14 category_64 category_128 category_132 category_134 portal_5 item_type_1 month_year_10_2026

<p>NOXA stability is regulated by the proteasome.</p> Prasanth Viswanathan (10314782) Justine R. Bersonda (25157885) Jackson Gill (25157888) Alyssandra Navarro (25157891) Allison C. Farrar (25157894) Thomas Caldarera (25157897) Andrew Murphy (341397) Daniel Dunham (25157900) Karl W. Boehme (11384016) Mark Manzano (25157903) Biochemistry Cell Biology Genetics Molecular Biology Cancer Hematology Infectious Diseases Virology systems biology approach regulating mitochondrial homeostasis primary effusion lymphoma immunoprecipitation experiments show endogenous reciprocal co emerging clinical relevance cell viability due newly appreciated interaction causes several malignancies unexpected genetic interaction findings thus provide div >< p marchf5 oncogenes may pel cells suggesting mcl1 motivated us genetic interaction tumor cells causes resistance thus investigated therapeutic potential survival role significant increase protein complex previously shown pel ). mechanistic link kaposi ’ fitness advantage e3 ligase drug development dimerization activities crispr knockout combination therapies chemotherapy regimens attractive target associated herpesvirus apoptotic signal apoptotic activities antiviral signaling <p>A. Western blots of PEL cell lines were treated with DMSO or 1.25 μM MG132 for 4 hours. B. Quantification of Western blots in panel A normalized to total protein stain and DMSO-treated cells. Statistical differences were calculated using paired t tests between untreated and MG132 treated in each cell line. Error bars, standard error of the mean.</p> 2026-10-01T17:54:28Z Image Figure 10.1371/journal.ppat.1014665.g007 https://figshare.com/articles/figure/_p_NOXA_stability_is_regulated_by_the_proteasome_p_/34049135 CC BY 4.0