2026-10-12T00:46:11Z https://api.figshare.com/v2/oai

oai:figshare.com:article/34049102 2026-10-01T17:42:48Z category_4 category_12 category_13 category_14 category_64 category_128 category_132 category_134 portal_5 item_type_3 month_year_10_2026

<p>The Top 100 Codependencies of MCL1 and MARCHF5 downloaded from the Cancer Dependency Map 23Q4.</p> Prasanth Viswanathan (10314782) Justine R. Bersonda (25157885) Jackson Gill (25157888) Alyssandra Navarro (25157891) Allison C. Farrar (25157894) Thomas Caldarera (25157897) Andrew Murphy (341397) Daniel Dunham (25157900) Karl W. Boehme (11384016) Mark Manzano (25157903) Biochemistry Cell Biology Genetics Molecular Biology Cancer Hematology Infectious Diseases Virology systems biology approach regulating mitochondrial homeostasis primary effusion lymphoma immunoprecipitation experiments show endogenous reciprocal co emerging clinical relevance cell viability due newly appreciated interaction causes several malignancies unexpected genetic interaction findings thus provide div >< p marchf5 oncogenes may pel cells suggesting mcl1 motivated us genetic interaction tumor cells causes resistance thus investigated therapeutic potential survival role significant increase protein complex previously shown pel ). mechanistic link kaposi ’ fitness advantage e3 ligase drug development dimerization activities crispr knockout combination therapies chemotherapy regimens attractive target associated herpesvirus apoptotic signal apoptotic activities antiviral signaling <p>The Top 100 Codependencies of MCL1 and MARCHF5 downloaded from the Cancer Dependency Map 23Q4.</p> 2026-10-01T17:54:28Z Dataset Dataset 10.1371/journal.ppat.1014665.s001 https://figshare.com/articles/dataset/_p_The_Top_100_Codependencies_of_MCL1_and_MARCHF5_downloaded_from_the_Cancer_Dependency_Map_23Q4_p_/34049102 CC BY 4.0