2026-10-10T16:14:58Z
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2026-10-01T17:40:08Z
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<p>Map to model fit and estimated local resolution for final 3D reconstructions of Fabs bound to WIV1 spike protomer.</p>
Ayush Upadhyay (25157573)
Jeffrey Seow (9415776)
Yilmaz Alguel (24840073)
Joseph Newman (5638340)
Nazia Thakur (9904162)
Abigail L. Hay (25157576)
Jerry C. H. Tam (13955938)
Andrea Nans (5176226)
Richard J. Orton (7832015)
Dalan Bailey (193037)
Peter Cherepanov (369)
Katie J. Doores (346210)
Biophysics
Microbiology
Evolutionary Biology
Ecology
Immunology
Biological Sciences not elsewhere classified
Hematology
Infectious Diseases
Virology
v1wt_06 contact residues
therapeutic antibody development
reactive monoclonal antibodies
mab v1wt_06 binds
increasing spillover potential
human population presents
heavy chain alone
future therapeutic use
confer broad sarbecovirus
circulating viruses suggesting
2 variant neutralisation
2 variants
xlink ">
virus entry
urgent need
rationale design
rational design
neutralising epitopes
including xec
ideal candidates
highly conserved
functionally constrained
discover cross
differing angles
continuing evolution
ace2 competition
<p><b>A)</b> Panel displaying the overall map to model fit for V1WT_06 Fab (red) bound to WIV1 spike (blue). The insets show a zoomed in view of the Fab-spike interface. The reconstruction is coloured by estimated local resolution (cryoSparc) overlayed on B-factor sharpened maps, colour scheme provided on the right. <b>B)</b> Panel displaying the overall map to model fit for V1WT_41 Fab (red) bound to WIV1 spike (blue). The insets show a zoomed in view of the Fab-spike interface. The reconstruction is coloured by estimated local resolution (cryoSparc) overlayed on B-factor sharpened maps, colour scheme provided on the right. <b>C)</b> Panel displaying the overall map to model fit for VA14_26 Fab (red) bound to WIV1 spike (blue). The insets show a zoomed in view of the Fab-spike interface. The reconstruction is coloured by estimated local resolution (cryoSparc) overlayed on B-factor sharpened maps, colour scheme provided on the right.</p> <p>(TIF)</p>
2026-10-01T17:40:02Z
Image
Figure
10.1371/journal.pbio.3003882.s003
https://figshare.com/articles/figure/_p_Map_to_model_fit_and_estimated_local_resolution_for_final_3D_reconstructions_of_Fabs_bound_to_WIV1_spike_protomer_p_/34048906
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