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2026-10-01T17:36:38Z
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<p>Physiological state discovery and characterization in eICU-CRD.</p>
Ali Namvar (9279350)
Sundaresh Ram (10428439)
Wassim W. Labaki (10704446)
Stefanie Galban (10428445)
Njira L. Lugogo (13119569)
Craig J. Galban (10428469)
Biophysics
Genetics
Biotechnology
Biological Sciences not elsewhere classified
Information Systems not elsewhere classified
Mathematical Sciences not elsewhere classified
Inorganic Chemistry
Hematology
track physiological instability
support clinical assessment
provide limited insight
multidimensional physiological space
monitoring systems face
method &# 8217
existing approaches rely
distinct clinical signatures
applies geometric analysis
6 %, 16
movement toward higher
state trajectory representation
physiological state monitoring
linking state dynamics
derived physiological states
aware monitoring ),
mortality prediction achieved
evaluated stream using
fold higher mortality
icu stay within
expected calibration error
routine icu data
fold higher
expected state
icu mortality
state outliers
risk states
respectively ),
remained within
outcome prediction
nearest state
assigned states
vital signs
strong discrimination
static thresholds
spent less
severity scores
laboratory values
interpretable patterns
external validation
excellent calibration
driven framework
discover data
developed stream
critical gap
8 hours
72 hours
002 ).
<p>(A) Unsupervised state discovery. STREAM identifies five recurrent data-derived physiological states (States 1–5) across ICU snapshots from pre-admission through day 10. (B) State clinical signatures. Bar plots show the top variables characterizing each state. State 1: calcium, platelets, chloride, MCH, MCV. State 2: BUN, bicarbonate, creatinine, anion gap, RDW. State 3: bicarbonate, WBC, potassium. State 4: platelets, MCHC, BUN, RDW. State 5: platelets, GCS minimum, SpO<sub>2</sub> minimum, creatinine. <i>Abbreviations: BUN, blood urea nitrogen; WBC, white blood cell count; MCHC, mean corpuscular hemoglobin concentration; GCS, Glasgow Coma Scale; SpO<sub>2</sub>, oxygen saturation; MCH, mean corpuscular hemoglobin; MCV, mean corpuscular volume; RDW, red cell distribution width.</i></p>
2026-10-01T17:36:17Z
Image
Figure
10.1371/journal.pdig.0001753.g002
https://figshare.com/articles/figure/_p_Physiological_state_discovery_and_characterization_in_eICU-CRD_p_/34048778
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