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oai:figshare.com:article/34048613 2026-10-01T17:34:55Z category_7 category_12 category_13 category_14 category_46 category_734 category_132 portal_5 item_type_1 month_year_10_2026

<p>Protein-level evidence integration and prioritization of shared OA-OP candidates.</p> Jiayin Pang (4862023) Yu Li (183836) Zhichao Qi (107502) Wenbin Yang (661259) Medicine Cell Biology Genetics Molecular Biology Immunology Biological Sciences not elsewhere classified Infectious Diseases weighted gene co showed greater attenuation robust rank aggregation prespecified score threshold osteogenic stromal compartments integrating interaction topology expression network analysis evaluated network configurations derived carnival scores analyzed independently within 53 retained pair global null expectation xlink "> osteoarthritis shared biological processes context evidence retained 39 evaluable candidate osteoporosis frequently coexist least one compartment four evaluable configurations first multilayer public extracellular matrix organization data integration framework preserving null model positive module pairs osteoporosis </ p whereas hsp90aa1 exceeded first public data integration positive pairs null calibration shared axis osteoarthritis synovium module correspondences highest model genetic evidence candidate genes supported pairs positive coexpression total number tissue support specific support specific structure signaling priors related monocytes recalculation using ranked candidates provide candidates primary matched osteoclast differentiation older adults <p>(A) Integrated ranking of the top 15 proteins according to the composite priority score, with the three highest-ranked proteins highlighted. (B) Profiles of the six normalized evidence dimensions for the top 10 proteins. Values correspond to those reported in <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0359583#pone.0359583.t002" target="_blank">Table 2</a>, and right-side labels identify the largest evidence dimension for each protein. (C) OmniPath neighborhood of the leading proteins. Colored nodes indicate prioritized proteins, gray nodes indicate shared connector genes, and directed edges indicate curated signaling relationships. (D) Genetic-evidence and protein-feasibility profiles of the leading proteins. Point size represents cell-type specificity, and asterisks identify proteins with model-derived CARNIVAL score of at least 0.1 in the selected CARNIVAL configuration. OA, osteoarthritis; OP, osteoporosis. Degree- and annotation-aware sensitivity results are shown in <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0359583#pone.0359583.s015" target="_blank">S6 Fig</a> and <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0359583#pone.0359583.s007" target="_blank">S7 Table</a>.</p> 2026-10-01T17:34:29Z Image Figure 10.1371/journal.pone.0359583.g004 https://figshare.com/articles/figure/_p_Protein-level_evidence_integration_and_prioritization_of_shared_OA-OP_candidates_p_/34048613 CC BY 4.0