2026-10-11T23:26:23Z https://api.figshare.com/v2/oai

oai:figshare.com:article/34048610 2026-10-01T17:34:54Z category_7 category_12 category_13 category_14 category_46 category_734 category_132 portal_5 item_type_1 month_year_10_2026

<p>Layered shared-axis evidence and permutation-calibrated OA-OP module correspondence.</p> Jiayin Pang (4862023) Yu Li (183836) Zhichao Qi (107502) Wenbin Yang (661259) Medicine Cell Biology Genetics Molecular Biology Immunology Biological Sciences not elsewhere classified Infectious Diseases weighted gene co showed greater attenuation robust rank aggregation prespecified score threshold osteogenic stromal compartments integrating interaction topology expression network analysis evaluated network configurations derived carnival scores analyzed independently within 53 retained pair global null expectation xlink "> osteoarthritis shared biological processes context evidence retained 39 evaluable candidate osteoporosis frequently coexist least one compartment four evaluable configurations first multilayer public extracellular matrix organization data integration framework preserving null model positive module pairs osteoporosis </ p whereas hsp90aa1 exceeded first public data integration positive pairs null calibration shared axis osteoarthritis synovium module correspondences highest model genetic evidence candidate genes supported pairs positive coexpression total number tissue support specific support specific structure signaling priors related monocytes recalculation using ranked candidates provide candidates primary matched osteoclast differentiation older adults <p>(A) Numbers of genes meeting the cumulative direction-consistency, shared-pathway, and module-correspondence criteria. Layer 3 contained 810 genes occurring in at least one criteria-positive OA-OP module pair. (B) Representative shared biological processes involving immune activation, antigen presentation, extracellular-matrix remodeling, and bone remodeling. (C) Disease-specific WGCNA blocks and numbers of retained disease-associated modules. Six eligible blocks produced 234 criteria-positive cross-disease module pairs. (D) Numbers of criteria-positive pairs and pairs with empirical FDR < 0.05 in each OA-OP block combination. Fifty-three of 464 tested module combinations had empirical FDR < 0.05. The total criteria-positive count was 234 compared with a null mean of 254.83 and a 95% interval of 242–267. OA, osteoarthritis; OP, osteoporosis; FDR, false discovery rate.</p> 2026-10-01T17:34:29Z Image Figure 10.1371/journal.pone.0359583.g003 https://figshare.com/articles/figure/_p_Layered_shared-axis_evidence_and_permutation-calibrated_OA-OP_module_correspondence_p_/34048610 CC BY 4.0