2026-10-12T01:04:58Z https://api.figshare.com/v2/oai

oai:figshare.com:article/34048607 2026-10-01T17:34:53Z category_7 category_12 category_13 category_14 category_46 category_734 category_132 portal_5 item_type_1 month_year_10_2026

<p>Robust disease signatures and enriched biological programs in osteoarthritis and osteoporosis.</p> Jiayin Pang (4862023) Yu Li (183836) Zhichao Qi (107502) Wenbin Yang (661259) Medicine Cell Biology Genetics Molecular Biology Immunology Biological Sciences not elsewhere classified Infectious Diseases weighted gene co showed greater attenuation robust rank aggregation prespecified score threshold osteogenic stromal compartments integrating interaction topology expression network analysis evaluated network configurations derived carnival scores analyzed independently within 53 retained pair global null expectation xlink "> osteoarthritis shared biological processes context evidence retained 39 evaluable candidate osteoporosis frequently coexist least one compartment four evaluable configurations first multilayer public extracellular matrix organization data integration framework preserving null model positive module pairs osteoporosis </ p whereas hsp90aa1 exceeded first public data integration positive pairs null calibration shared axis osteoarthritis synovium module correspondences highest model genetic evidence candidate genes supported pairs positive coexpression total number tissue support specific support specific structure signaling priors related monocytes recalculation using ranked candidates provide candidates primary matched osteoclast differentiation older adults <p>(A) OA signature genes prioritized by integration across four OA bulk cohorts. The panel presents the highest-ranked genes and selected genes representing antigen presentation, inflammatory signaling, and matrix or tissue-response processes. (B) OP signature genes prioritized across four OP bulk cohorts, together with selected genes representing bone remodeling, immune and antigen-presentation activity, and bone or matrix adaptation. (C) Representative Gene Ontology biological processes enriched in the OA signature. (D) Representative Gene Ontology biological processes enriched in the OP signature. (E) Cross-cohort effects of the displayed genes. Cell color indicates the signed within-dataset effect, asterisks indicate cohort-level FDR < 0.05, and NA indicates unavailable mapping. Complete cohort-level gene and pathway results are provided in the accompanying data files. OA, osteoarthritis; OP, osteoporosis; GO, Gene Ontology; FDR, false discovery rate.</p> 2026-10-01T17:34:29Z Image Figure 10.1371/journal.pone.0359583.g002 https://figshare.com/articles/figure/_p_Robust_disease_signatures_and_enriched_biological_programs_in_osteoarthritis_and_osteoporosis_p_/34048607 CC BY 4.0