2026-10-12T15:46:33Z https://api.figshare.com/v2/oai

oai:figshare.com:article/34048520 2026-10-01T17:34:08Z category_4 category_7 category_12 category_13 category_14 category_16 category_272 category_106 category_502 category_734 category_122 portal_5 item_type_3 month_year_10_2026

<p>Full transcription factor activity matrix across all three conditions.</p> Niraj Shah (5325059) Biochemistry Medicine Cell Biology Genetics Molecular Biology Physiology Environmental Sciences not elsewhere classified Science Policy Astronomical and Space Sciences not elsewhere classified Biological Sciences not elsewhere classified Mental Health tibialis anterior muscle stress regulators pml muscle wasting broadly much larger pool gse273092 gastrocnemius muscle gse145480 gastrocnemius muscle decoupler &# 8217 collectri mouse regulon chromatin remodeller smarca4 biologically coherent set univariate linear model tf activity profiles infer tf activity old versus 8 level wald statistics atrophy regulators included atrophy regulators dominated specific regulators encoding glucocorticoid receptor nr3c1 732 tfs scored 165 tfs ). disuse atrophy model spaceflight showed repression 3 %) condition 0 %) partial 4 %) 226 tf old mice level overlap 1459 ). disuse atrophy transcription factors ten days target interactions stat1 crossed specific based sarcopenia model rodent research prior studies pearson correlation nasa osd mice subjected foxo signaling discordant pattern comparative analysis bearing controls <p>Normalized enrichment scores (NES) and Benjamini-Hochberg adjusted p-values (p_adj) from decoupleR ULM scoring are reported for all 732 transcription factors evaluated in the spaceflight, sarcopenia, and disuse atrophy contrasts. Each TF is assigned to one of four activity categories (Pan-Atrophy, Partial, Condition-Specific, None) based on the number of conditions in which |NES| ≥ 1.5, with the direction of significant activity in each condition (sig_directions) also reported.</p> <p>(CSV)</p> 2026-10-01T17:34:04Z Dataset Dataset 10.1371/journal.pone.0359659.s002 https://figshare.com/articles/dataset/_p_Full_transcription_factor_activity_matrix_across_all_three_conditions_p_/34048520 CC BY 4.0