2026-10-12T16:27:26Z
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2026-10-01T17:31:19Z
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<p>Representative hematoxylin and eosin-stained nasal mucosal sections from all experimental groups.</p>
Naim Gheymoumi (25157753)
Sevda Shayesteh (25157756)
Fatemeh Sharifi (3496619)
Marziyeh Amiri-Andebili (25157759)
Hediyeh Gheymoumi (25157762)
Biochemistry
Medicine
Microbiology
Cell Biology
Molecular Biology
Physiology
Biotechnology
Chemical Sciences not elsewhere classified
Immunology
Cancer
Infectious Diseases
potential immunometabolic modulator
following ova sensitization
endogenous tryptophan metabolite
elevated serum ige
aryl hydrocarbon receptor
serum inflammatory markers
including increased sneezing
mucosal immune regulation
systemic inflammatory mediators
study investigated kyna
findings support kyna
marked inflammatory changes
xlink "> rats
local regulatory cytokines
ar remain unclear
systemic effects comparable
ahr signaling contributes
xlink ">
regulatory cytokines
systemic anti
inflammatory infiltration
histopathological changes
inflammatory effects
cytokine regulation
associated regulation
ahr signaling
kyna ),
splenic tissues
splenic histopathology
kynurenic acid
indicating involvement
immunomodulatory properties
greater improvement
epithelial damage
behavioral responses
associated proteins
<p>(Edema: o; eosinophilic infiltrate: arrows; abnormal epithelium: asterisk). The AR group showed marked epithelial disruption, submucosal edema, and inflammatory cell infiltration compared with the control group. KYNA and desloratadine treatment attenuated these histopathological alterations. Samples include (A) Control, (B) AR, (C) Al(OH)<sub>3</sub>, (D) KYNA, and (E) desloratadine groups. All images were obtained at ×40 magnification.</p>
2026-10-01T17:31:10Z
Image
Figure
10.1371/journal.pone.0359624.g004
https://figshare.com/articles/figure/_p_Representative_hematoxylin_and_eosin-stained_nasal_mucosal_sections_from_all_experimental_groups_p_/34048235
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