2026-10-12T06:24:03Z https://api.figshare.com/v2/oai

oai:figshare.com:article/34048232 2026-10-01T17:31:18Z category_4 category_7 category_8 category_12 category_14 category_16 category_21 category_873 category_46 category_64 category_132 portal_5 item_type_1 month_year_10_2026

<p>Histopathological scoring and organ index analysis across experimental groups.</p> Naim Gheymoumi (25157753) Sevda Shayesteh (25157756) Fatemeh Sharifi (3496619) Marziyeh Amiri-Andebili (25157759) Hediyeh Gheymoumi (25157762) Biochemistry Medicine Microbiology Cell Biology Molecular Biology Physiology Biotechnology Chemical Sciences not elsewhere classified Immunology Cancer Infectious Diseases potential immunometabolic modulator following ova sensitization endogenous tryptophan metabolite elevated serum ige aryl hydrocarbon receptor serum inflammatory markers including increased sneezing mucosal immune regulation systemic inflammatory mediators study investigated kyna findings support kyna marked inflammatory changes xlink "> rats local regulatory cytokines ar remain unclear systemic effects comparable ahr signaling contributes xlink "> regulatory cytokines systemic anti inflammatory infiltration histopathological changes inflammatory effects cytokine regulation associated regulation ahr signaling kyna ), splenic tissues splenic histopathology kynurenic acid indicating involvement immunomodulatory properties greater improvement epithelial damage behavioral responses associated proteins <p>(A) Nasal mucosal inflammation score, (B) splenic histopathological alteration score, and (C) spleen-to-body weight ratio. Data are presented as mean ± SEM (n = 8). **P < 0.01 and ***P < 0.001 vs. Control; ###P < 0.001 vs. AR; &&P < 0.01 vs. KYNA.</p> 2026-10-01T17:31:10Z Image Figure 10.1371/journal.pone.0359624.g003 https://figshare.com/articles/figure/_p_Histopathological_scoring_and_organ_index_analysis_across_experimental_groups_p_/34048232 CC BY 4.0