2026-10-14T20:46:40Z
https://api.figshare.com/v2/oai
oai:figshare.com:article/34048159
2026-10-01T17:30:37Z
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<p>Identification of DEGs in pSIOs after LPS treatment.</p>
Sumin Park (1418677)
Boram Lee (549836)
Dahye Kim (4750968)
Sheet Sunirmal (25157743)
Min Gook Lee (25157746)
Haesun Lee (13907847)
Sun A. Ock (17671438)
Jae Gyu Yoo (18291035)
Biophysics
Biochemistry
Microbiology
Cell Biology
Genetics
Molecular Biology
Physiology
Chemical Sciences not elsewhere classified
Science Policy
Immunology
Biological Sciences not elsewhere classified
Infectious Diseases
potentially reducing reliance
cell models fail
adult jejunum stimulated
functional categories associated
bile acid signaling
div >< p
cytokine gene expression
studying intestinal inflammation
intestinal tract
associated diseases
receptor signaling
inflammatory signaling
vitro </
valuable platform
transcriptome analysis
time pcr
thereby posing
related pathways
proteins involved
physiologically relevant
nutrient transport
major threat
inflammatory stress
induced alterations
increased tlr4
including enrichment
immunofluorescence staining
findings demonstrate
enriched pathways
barrier maintenance
barrier integrity
animal testing
analyzing changes
altered expression
3rs principle
<p>(A) Total number of upregulated and downregulated DEGs (<i>p</i> ≤ 0.05 and |log2 fold-change| ≥ 1). (B) Top 10 upregulated and downregulated DEGs ranked by fold change. (C) Volcano plot of DEGs with top five genes highlighted. (D) Heatmap and hierarchical clustering of the top 100 DEGs. RNA sequencing was performed using one pooled RNA sample generated from three organoid wells for each experimental group, resulting in one biological replicate (n = 1) per group. DEG, differentially expressed gene.</p>
2026-10-01T17:30:26Z
Image
Figure
10.1371/journal.pone.0359086.g006
https://figshare.com/articles/figure/_p_Identification_of_DEGs_in_pSIOs_after_LPS_treatment_p_/34048159
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