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oai:figshare.com:article/34048049 2026-10-01T17:29:41Z category_4 category_7 category_12 category_13 category_14 category_21 category_272 category_873 category_39 category_734 category_132 category_133 category_134 portal_5 item_type_1 month_year_10_2026

<p>Proposed pathway for sesquiterpenoid biosynthesis in <i>Eupatorium lindleyanum.</i></p> Yingzhe Wang (386669) Pan Jiang (732780) Jiaqiu Yuan (25157732) Jinghan Wu (16701969) Yue Zhang (30585) Kun Guo (283211) Biochemistry Medicine Cell Biology Genetics Molecular Biology Biotechnology Environmental Sciences not elsewhere classified Chemical Sciences not elsewhere classified Ecology Biological Sciences not elsewhere classified Infectious Diseases Plant Biology Virology weighted gene co three major groups roots — lacks regulatory basis underlying molecular breeding aimed first comprehensive view expression network analysis compounds — abundant cluster 3 ). yielding 147743 unigenes cluster 2 ), eupatorium lindleyanum </ pharmacologically active sesquiterpenoids medicinal plant rich exhibiting distinct tissue specific accumulation patterns potential regulators based specific sesquiterpenoid biosynthesis medicinal plant specific biosynthesis specific accumulation sesquiterpenoid biosynthesis dsms ), based metabolomics 88 unigenes preferential accumulation wrky </ pmk </ nes1 </ nac </ myb </ mvk </ mvd </ isph </ ispg </ ispf </ ispe </ ispd </ idi </ hmgcs </ hmgcr </ gds </ gas </ gao </ fldh </ fdps </ erf </ <p>The red, blue and yellow rectangles indicate levels of gene expression. MVA: mevalonate pathway; MEP: 2-C-methyl-D-erythritol 4-phosphate pathway; GAO: germacrene A oxidase; GAS: germacrene A synthase; PMK: phosphomevalonate kinase; ACAT: acetyl-CoA acetyltransferase; HMGCS: hydroxymethylglutaryl-CoA synthase; HMGCR: hydroxymethylglutaryl-CoA reductase; MVK: mevalonate kinase; MVD: diphosphomevalonate decarboxylase; FDPS: farnesyl diphosphate synthase; IDI: isopentenyl-diphosphate Delta-isomerase; dxs: 1-deoxy-D-xylulose-5-phosphate synthase; dxr: 1-deoxy-D-xylulose-5-phosphate reductoisomerase; ispD: 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase; ispE: 4-(cytidine 5’-diphospho)-2-C-methyl-D-erythritol kinase; ispF: 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase; ispG: (E)-4-hydroxy-3-methylbut-2-enyl-diphosphate synthase; ispH: 4-hydroxy-3-methylbut-2-en-1-yl diphosphate reductase; FLDH: NAD + -dependent farnesol dehydrogenase; NES1: (3S,6E)-nerolidol synthase; GDS: germacrene D synthase.</p> 2026-10-01T17:29:29Z Image Figure 10.1371/journal.pone.0359566.g006 https://figshare.com/articles/figure/_p_Proposed_pathway_for_sesquiterpenoid_biosynthesis_in_i_Eupatorium_lindleyanum_i_p_/34048049 CC BY 4.0