2026-10-10T20:43:40Z https://api.figshare.com/v2/oai

oai:figshare.com:article/34047661 2026-10-01T17:26:25Z category_12 category_13 category_14 category_734 category_811 category_64 portal_5 item_type_1 month_year_10_2026

<p>BRAF mutation frequency by tumor location (proximal colon, distal colon, rectum) in EOCRC vs LOCRC.</p> Elif Sertesen Çamöz (25157677) Osman Bilge Kaya (24267303) Hakan Erçelebi (25157680) Cengiz Karaçin (25157683) Yunus Kasım Terzi (25157686) Zerrin Yılmaz Çelik (25157689) Cell Biology Genetics Molecular Biology Biological Sciences not elsewhere classified Mathematical Sciences not elsewhere classified Cancer strong independent predictor significantly less frequent several prior studies onset colorectal cancer multivariate cox regression least partially explained cancer genome atlas meier overall survival somatic mutation frequencies braf v600e specifically meier median os braf mutation frequency tumor location attenuated specific multivariate model 254 crc patients crc prognostic biomarkers braf mutation depletion tumor location adjustment sample type adjustment eocrc ), defined validation cohort ). tcga pancancer atlas xlink "> early 001 ), nras impact cohort adjusted somatic mutation pancancer atlas tumor location validation cohort prognostic biomarkers overall cohort xlink "> sample type crc diagnosed 009 ), braf depletion 001 ). tumor stage prognostic implications independently prognostic impact cohort discovery cohort <p>Left: TCGA. Right: MSK-IMPACT. Within-location BRAF differences are substantially smaller than unstratified comparisons, indicating that BRAF-EOCRC associations are at least partially explained by differential tumor location distribution.</p> 2026-10-01T17:26:21Z Image Figure 10.1371/journal.pone.0359094.g002 https://figshare.com/articles/figure/_p_BRAF_mutation_frequency_by_tumor_location_proximal_colon_distal_colon_rectum_in_EOCRC_vs_LOCRC_p_/34047661 CC BY 4.0