2026-10-12T01:44:34Z https://api.figshare.com/v2/oai

oai:figshare.com:article/34047649 2026-10-01T17:26:17Z category_4 category_12 category_21 category_873 category_64 category_134 portal_5 item_type_1 month_year_10_2026

<p>Histopathological effects of different doses of crocin and orlistat on liver tissue in the studied groups, based on H&E staining (400×).</p> Hossain Rezayee (25157659) Mohammad Ali Fahmidehkar (25157662) Farimah Beheshti (4791291) Mohsen Ghoryani (25157665) Yaser Yousefpoor (25157668) Dawood Hossaini (25157671) Davod Ilbeigi (25157674) Biochemistry Cell Biology Biotechnology Chemical Sciences not elsewhere classified Cancer Virology containing seven rats confirmed marked improvement alkaline phosphatase levels increased hepatic malondialdehyde xlink "> forty present study demonstrate liver function enzymes hepatic structural alterations hepatic lipid accumulation oxidative stress biomarkers serum lipid profiles xlink "> non xlink "> high xlink "> oxidative stress hepatic steatosis study aims lipid profile histopathological alterations fatty liver therapeutic agent rat model nitrite concentrations inflammatory infiltration histopathological evaluation four weeks eight weeks antioxidant status animal model alanine aminotransferase <p>Experimental groups (n = 7 per group) were defined as follows: ND, normal diet (control group); HFD, high-fat diet (Fat) group; Cr10, Cr30, and Cr50, animals receiving crocin at doses of 10, 30, and 50 mg/kg body weight, respectively; Orl, animals treated with orlistat. Representative H&E-stained liver sections are shown for: A: normal diet; B, B1: HFD; C, C1: HFD + crocin 10 mg/kg; D: HFD + crocin 30 mg/kg; E: HFD + crocin 50 mg/kg and F: HFD + orlistat 10 mg/kg. Arrows in images B, C, and D indicate hepatocellular ballooning (foam cells), while arrows in images B1 and C1 highlight lymphocyte infiltration (inflammation).</p> 2026-10-01T17:26:12Z Image Figure 10.1371/journal.pone.0357768.g004 https://figshare.com/articles/figure/_p_Histopathological_effects_of_different_doses_of_crocin_and_orlistat_on_liver_tissue_in_the_studied_groups_based_on_H_E_staining_400_p_/34047649 CC BY 4.0