2026-10-12T01:04:57Z
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2026-10-01T17:26:15Z
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<p>The effect of different doses of crocin and orlistat administration on serum liver enzyme levels in the studied groups.</p>
Hossain Rezayee (25157659)
Mohammad Ali Fahmidehkar (25157662)
Farimah Beheshti (4791291)
Mohsen Ghoryani (25157665)
Yaser Yousefpoor (25157668)
Dawood Hossaini (25157671)
Davod Ilbeigi (25157674)
Biochemistry
Cell Biology
Biotechnology
Chemical Sciences not elsewhere classified
Cancer
Virology
containing seven rats
confirmed marked improvement
alkaline phosphatase levels
increased hepatic malondialdehyde
xlink "> forty
present study demonstrate
liver function enzymes
hepatic structural alterations
hepatic lipid accumulation
oxidative stress biomarkers
serum lipid profiles
xlink "> non
xlink "> high
xlink ">
oxidative stress
hepatic steatosis
study aims
lipid profile
histopathological alterations
fatty liver
therapeutic agent
rat model
nitrite concentrations
inflammatory infiltration
histopathological evaluation
four weeks
eight weeks
antioxidant status
animal model
alanine aminotransferase
<p>Serum activities of (A) Alanine Aminotransferase (ALT), (B) Aspartate Aminotransferase (AST), and (C) Alkaline Phosphatase (ALP) were measured as biochemical indicators of liver function. Experimental groups (n = 7 per group) were defined as follows: ND, normal diet (control group); HFD, high-fat diet (Fat) group; Cr10, Cr30, and Cr50, animals receiving crocin at doses of 10, 30, and 50 mg/kg body weight, respectively; Orl, animals treated with orlistat. Data are presented as mean ± SD. <sup>##</sup> p < 0.01, <sup>###</sup>p < 0.001 compared to the group receiving ND. *p < 0.05, **p < 0.01 and ***p < 0.001 compared to the HFD.</p>
2026-10-01T17:26:12Z
Image
Figure
10.1371/journal.pone.0357768.g002
https://figshare.com/articles/figure/_p_The_effect_of_different_doses_of_crocin_and_orlistat_administration_on_serum_liver_enzyme_levels_in_the_studied_groups_p_/34047643
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