2026-10-11T18:40:06Z
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2026-10-01T17:23:43Z
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<p>Modelled antibody trajectories for nine participants with inferred exposure events.</p>
Mhairi J. McCormack (25157587)
Louis Banda (5632649)
Stephen Kasenda (6844046)
Ellen C. Hughes (25157590)
Amelia Crampin (272631)
Abena S. Amoah (8605329)
Jonathan M. Read (9159869)
Antonia Ho (10214054)
Brian J. Willett (11450469)
James A. Hay (6066002)
Medicine
Microbiology
Biotechnology
Ecology
Immunology
Mathematical Sciences not elsewhere classified
Cancer
Infectious Diseases
Virology
Computational Biology
level bayesian model
boosting following reinfection
april 2022 ).
acute boost remaining
accurate epidemiological inference
403 &# 8211
027 &# 8211
rapid waning underscores
679 neutralising antibody
reconstruct infection histories
quantify antibody kinetics
limited routine surveillance
particularly among adults
malawi </ p
infection histories
routine surveillance
antibody waning
antibody kinetics
uninfected participants
understanding transmission
traditional seroconversion
three months
sustained protection
serological measurements
saharan africa
responses varied
regional differences
reactivity suggests
prior variants
one year
measured using
individuals clustering
improved understanding
high responders
finding populations
declined rapidly
complicating interpretation
based thresholds
ancestral b
analysed 15
675 unvaccinated
41 vs
<p>Each panel represents an individual, with the x-axis showing time periods and the y-axis the log<sub>3</sub>(titre/50) antibody titre. Measured titres are indicated by diamonds, coloured by assay variant. Solid lines represent the modelled posterior mean trajectories, with shaded areas showing 95% prediction intervals. Orange bars indicate the posterior probability of infection at each time point, with darker shading representing higher probability. No BA.2 trajectory is shown for individual 943 due to the absence of a sample in the final survey (Q1 2022).</p>
2026-10-01T17:23:08Z
Image
Figure
10.1371/journal.pgph.0007133.g004
https://figshare.com/articles/figure/_p_Modelled_antibody_trajectories_for_nine_participants_with_inferred_exposure_events_p_/34047466
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