2026-10-11T11:02:06Z https://api.figshare.com/v2/oai

oai:figshare.com:article/34047439 2026-10-01T17:23:33Z category_7 category_8 category_21 category_39 category_46 category_811 category_64 category_132 category_134 category_135 portal_5 item_type_1 month_year_10_2026

<p>Proportion of participants experiencing first-time seroconversion across four sequential surveys in the rural (Karonga, orange) and urban (Lilongwe, green) sites.</p> Mhairi J. McCormack (25157587) Louis Banda (5632649) Stephen Kasenda (6844046) Ellen C. Hughes (25157590) Amelia Crampin (272631) Abena S. Amoah (8605329) Jonathan M. Read (9159869) Antonia Ho (10214054) Brian J. Willett (11450469) James A. Hay (6066002) Medicine Microbiology Biotechnology Ecology Immunology Mathematical Sciences not elsewhere classified Cancer Infectious Diseases Virology Computational Biology level bayesian model boosting following reinfection april 2022 ). acute boost remaining accurate epidemiological inference 403 &# 8211 027 &# 8211 rapid waning underscores 679 neutralising antibody reconstruct infection histories quantify antibody kinetics limited routine surveillance particularly among adults malawi </ p infection histories routine surveillance antibody waning antibody kinetics uninfected participants understanding transmission traditional seroconversion three months sustained protection serological measurements saharan africa responses varied regional differences reactivity suggests prior variants one year measured using individuals clustering improved understanding high responders finding populations declined rapidly complicating interpretation based thresholds ancestral b analysed 15 675 unvaccinated 41 vs <p>Bars indicate the fraction of participants who seroconverted in each survey, with 95% binomial confidence intervals shown. Surveys were conducted as follows: Survey 1 (24 Feb–8 Jun 2021), Survey 2 (28 Jun–13 Sep 2021), Survey 3 (4 Oct–10 Dec 2021), and Survey 4 (27 Jan–22 Apr 2022). A marked increase in seroconversion is evident in Survey 4.</p> <p>(PNG)</p> 2026-10-01T17:23:08Z Image Figure 10.1371/journal.pgph.0007133.s018 https://figshare.com/articles/figure/_p_Proportion_of_participants_experiencing_first-time_seroconversion_across_four_sequential_surveys_in_the_rural_Karonga_orange_and_urban_Lilongwe_green_sites_p_/34047439 CC BY 4.0