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<p>Binding dendrogram of SARS-CoV-2 monoclonal antibodies analysed by epitope binning.</p>
Nazia Thakur (9904162)
Joseph Newman (5638340)
Dongchun Ni (15188356)
Jeffrey Seow (9415776)
Abigail L. Hay (25157576)
Yeonjae Lee (12256119)
Ayush Upadhyay (25157573)
Babatunde E. Ekundayo (25157578)
John A. Hammond (7431785)
Thomas P. Peacock (6536120)
Kelvin Lau (1847764)
Katie J. Doores (346210)
Dalan Bailey (193037)
Microbiology
Cell Biology
Evolutionary Biology
Environmental Sciences not elsewhere classified
Ecology
Immunology
Biological Sciences not elsewhere classified
Cancer
Infectious Diseases
Virology
multiple bat coronaviruses
g ., rc
g ., civet
clade 1 viruses
restricted ace2 usage
mammalian ace2 proteins
g ., rhgb07
using monoclonal antibodies
clade 1 sarbecoviruses
div >< p
determined host range
converting enzyme 2
2 convalescent individuals
ace2 ), via
using binding assays
antigenicity using sera
related bat sarbecoviruses
using sarbecoviruses
host range
clade 3
pangolin ),
neutralising antibodies
entry assays
binding domain
sarbecoviruses interact
sarbecoviruses exhibited
rodent ace2
like rhgb07
generalist ace2
related antigenicity
zoonotic potential
vitally important
still evidence
specialist </
shifting pattern
robust evidence
research indicates
racoon dog
novel structure
largely maintained
including human
immunodominant target
human primate
generalist phenotypes
generalist </
especially omicron
entry phenotypes
diverse panel
continued evolution
breakthrough infections
<p><b>(A)</b> Dendrogram represents the relatedness of the epitopes of the antibodies. The cut-off for creating antibody communities is shown by the red line at 0.45. <b>(B)</b> Heatmap of antibody blocking and sandwiching interactions. Red boxes indicate blocking interactions, green indicates sandwiching interactions. Self-self blocking is indicated by red boxes with thicker black outlines. Antibodies immobilised as ligands are listed on the left and analytes injected are listed across the top. Where a monoclonal antibody failed to bind as a ligand, it has been excluded.</p> <p>(TIF)</p>
2026-10-01T17:40:07Z
Image
Figure
10.1371/journal.pbio.3003944.s011
https://figshare.com/articles/figure/_p_Binding_dendrogram_of_SARS-CoV-2_monoclonal_antibodies_analysed_by_epitope_binning_p_/34047343
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