2026-10-11T05:41:55Z https://api.figshare.com/v2/oai

oai:figshare.com:article/34047255 2026-10-01T17:07:45Z category_4 category_7 category_12 category_15 category_873 category_734 category_132 portal_63 item_type_6 month_year_10_2026

A pH-Dependent Curcumin–Iminosugar Hybrid Promotes GCase Enhancement and Reactive Oxygen Species Reduction Alessio Morano (25157547) Camilla Matassini (1546126) Francesca Cardona (310895) Damiano Tanini (4353448) Silvia Falliano (11070078) Amelia Morrone (5844863) Rebecca Sodano (25157550) Paolo Paoli (4047742) Andrea Goti (1546123) Francesca Clemente (6331733) Biochemistry Medicine Cell Biology Neuroscience Chemical Sciences not elsewhere classified Biological Sciences not elsewhere classified Infectious Diseases single molecular framework redox modulation within increased oxidative stress enhanced enzyme activity derived antioxidant motifs integrating gcase enhancement enhanced gcase activity dependent gcase modulation 2 </ b type fibroblasts related synucleinopathies promising lead parkinson ’ lysosomal conditions l444p gaucher ferulic acid Gaucher disease and Parkinson’s disease are characterized by β-glucocerebrosidase (GCase) dysfunction and increased oxidative stress. Here, we report two multifunctional hybrids that combine an iminosugar-based pharmacological chaperone scaffold with curcumin- or ferulic acid-derived antioxidant motifs. The curcumin-iminosugar hybrid <b>2</b> exhibits pH-dependent GCase modulation, enhanced GCase activity under lysosomal conditions, enhanced enzyme activity in L444P Gaucher and wild-type fibroblasts, and reduced intracellular reactive oxygen species (ROS) levels. By integrating GCase enhancement and redox modulation within a single molecular framework, compound <b>2</b> represents a promising lead for Gaucher disease and GCase-related synucleinopathies. 2026-10-01T00:00:00Z Text Journal contribution 10.1021/acsomega.6c08401.s001 https://figshare.com/articles/journal_contribution/A_pH-Dependent_Curcumin_Iminosugar_Hybrid_Promotes_GCase_Enhancement_and_Reactive_Oxygen_Species_Reduction/34047255 CC BY-NC 4.0