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oai:figshare.com:article/34046622 2026-10-01T15:31:43Z portal_1197 item_type_6 month_year_10_2026

Poly(oligo(ethylene glycol) vinyl acetate)s : a versatile class of thermoresponsive and biocompatible polymers Guillaume Hedir (4636921) Maria Chiara Arno (24891328) Marvin Langlais (3950198) Jonathan Husband (24891619) Rachel K. O'Reilly (2472382) Andrew P. Dove (1361232) Vinyl acetate Addition polymerization Migrated from ePrints Polymers with a thermally-triggered phase transition are important in the design of materials for biological applications where their behavior can be used to trigger release or (dis)assembly events. Despite their advantages, a system with tuneable thermal response, end-group reactive sites, low toxicity and controlled main-chain degradability has not been realised, yet would represent a significant advance. We report the versatile new poly(oligo(ethylene glycol) vinyl acetate)s with excellent control over their molecular properties obtained through RAFT/MADIX polymerization. Furthermore, we demonstrate structure-controlled thermal transitions, conjugation to human lysozyme through the retained end group and moreover show that this class of polymers can uniquely be copolymerized with 2-methylene-1,3-dioxepane (MDO) to generate polymers in which the degradability and cloud point can be independently tuned to create materials that display the same cloud point but degrade differently. 2017-06-30T00:00:00Z Text Journal contribution 10.1002/anie.201703763 https://figshare.com/articles/journal_contribution/Poly_oligo_ethylene_glycol_vinyl_acetate_s_a_versatile_class_of_thermoresponsive_and_biocompatible_polymers/34046622 CC BY 4.0