2026-10-14T06:47:09Z https://api.figshare.com/v2/oai

oai:figshare.com:article/34046542 2026-10-01T15:14:45Z category_7 category_12 category_45 category_46 category_734 portal_63 item_type_6 month_year_10_2026

Rice Bran Insoluble Dietary Fiber and Its Bound Polyphenols Alleviate Colitis by Regulating the Autophagy-NLRP3 Inflammasome Axis Li Liu (75607) Bing Zheng (1426309) Hui Ye (164331) Jianhua Xie (8396676) Yi Chen (38576) Xiaole Zhao (2603575) Yufei Hu (1544002) Xiaobo Hu (1393213) Qiang Yu (5487) Medicine Cell Biology Sociology Immunology Biological Sciences not elsewhere classified suppressed er stress protective effects via neglecting bound polyphenols nlrp3 inflammasome activation important functional component whereas rapa restored ridf ), rich important hub important contributors study demonstrates nlrp3 axis mtor cascade intestinal barrier improves colitis gut microbiome carbohydrate components ameliorated colitis alleviating colitis Although dietary fiber alleviates colonic inflammation, most studies have focused on carbohydrate components, neglecting bound polyphenols (BPs). Rice bran insoluble dietary fiber (RIDF), rich in BPs, improves colitis; however, how BPs work and their specific contributions remain elusive. Our study demonstrates that BPs are important contributors of RIDF in alleviating colitis. Relative to rice bran dietary fiber without BPs (RIDF_DF), RIDF markedly ameliorated colitis symptoms, mitigated endoplasmic reticulum stress (ER stress), restored the gut microbiome and metabolites, and blocked the PI3K/Akt/mTOR cascade and NLRP3 inflammasome activation. 3-MA abolished, whereas RAPA restored, these protective effects via the autophagy-NLRP3 axis, identifying this axis as an important hub. Collectively, BPs served as an important functional component of RIDF. They ameliorated colitis by activating the autophagy-NLRP3 axis, which suppressed ER stress, repaired the intestinal barrier, and restored the gut microbiome and metabolome. 2026-10-01T00:00:00Z Text Journal contribution 10.1021/acs.jafc.6c06416.s001 https://figshare.com/articles/journal_contribution/Rice_Bran_Insoluble_Dietary_Fiber_and_Its_Bound_Polyphenols_Alleviate_Colitis_by_Regulating_the_Autophagy-NLRP3_Inflammasome_Axis/34046542 CC BY-NC 4.0