2026-10-10T23:43:52Z https://api.figshare.com/v2/oai

oai:figshare.com:article/34046059 2026-10-01T13:35:45Z category_146 category_12 category_13 category_15 category_16 category_873 category_64 category_122 category_133 portal_63 item_type_6 month_year_10_2026

Dithiane-Enabled Divergent Ring Rearrangements for the Construction of Sulfur-Containing Semisaturated Fused Pyridines and Pyrroles Xiaomeng Gong (19346861) Guohong Tang (20069082) Yingying Xue (1781347) Rui-Peng Li (6848834) Shouchu Tang (1589563) Space Science Cell Biology Genetics Neuroscience Physiology Chemical Sciences not elsewhere classified Cancer Mental Health Plant Biology whereas oxidative lewis mediated ring expansion enables two reagent controlled rearrangement pathways dithiane unit functions relevant scaffolds n </ h </ dimensional drug containing semisaturated construct strain cis </ >- selective >- azirines Sulfur-containing semisaturated <i>N</i>-heterocycles represent valuable three-dimensional drug-relevant scaffolds, yet general divergent synthetic approaches remain scarce. Herein, we report a metal-free <i>cis</i>-selective [3 + 2] cycloaddition between alkynyl 1,3-dithianes and 2<i>H</i>-azirines to construct strain-encoded bicyclic aziridine intermediates. The 1,3-dithiane unit functions as a sulfur shuttle that enables two reagent-controlled rearrangement pathways: Brønsted-acid-mediated ring expansion through 1,2-sulfur migration affords sulfur-functionalized semisaturated fused pyridines, whereas oxidative Lewis-acid-promoted ring contraction furnishes sulfur-functionalized semisaturated fused pyrroles. 2026-10-01T00:00:00Z Text Journal contribution 10.1021/acs.orglett.6c03956.s001 https://figshare.com/articles/journal_contribution/Dithiane-Enabled_Divergent_Ring_Rearrangements_for_the_Construction_of_Sulfur-Containing_Semisaturated_Fused_Pyridines_and_Pyrroles/34046059 CC BY-NC 4.0