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oai:figshare.com:article/34046048 2026-10-01T13:34:02Z category_1 category_4 category_14 category_19 category_21 category_873 category_69 category_134 portal_63 item_type_6 month_year_10_2026

DES-Based Green Synthesis of 2D Fluorescent Molybdenum Disulfide for Highly Sensitive and Selective Detection of Nifedipine Rafee Ullah (25156691) Shams Ur Rehman (22257563) Adnan Khan (696190) Hui-Fen Wu (2247511) Biophysics Biochemistry Molecular Biology Pharmacology Biotechnology Chemical Sciences not elsewhere classified Inorganic Chemistry Virology surface passivating agent structurally similar compounds practical pharmacological monitoring photoluminescence spectroscopy revealing inner filter effect exceptionally low limit enhanced photoluminescence properties common metal ions based green synthesis green chemistry approach fluorescence quenching mechanism 2 </ sup yield ultrathin nanosheets level analyte detection ex </ sub em </ sub deficient nif molecules assisted 2d nanosheets effective approach assisted exfoliation 2d mos upon addition synthesized using study presents reaction medium quenched due ife ). hydrothermal method highly sensitive fluorescence probe effectively applied 420 nm 40 nm 330 nm Highly fluorescent 2D MoS_2–x nanosheets exhibiting intense blue emission were synthesized using a green chemistry approach, utilizing DES as both the reaction medium and a surface passivating agent. The material was synthesized via a hydrothermal method, followed by ultrasonication-assisted exfoliation to yield ultrathin nanosheets with enhanced photoluminescence properties. The 2D MoS_2–x nanosheets demonstrated strong fluorescence at λ_em = 420 nm when excited at λ_ex = 330 nm. These nanosheets were employed as a fluorescence probe for the detection of the calcium channel blocker drug nifedipine (NIF) via a fluorescence quenching mechanism. Upon addition of NIF, the fluorescence of the 2D MoS_2–x nanosheets was quenched due to electron transfer from the nanosheets to the electron-deficient NIF molecules, combined with the inner filter effect (IFE). The nanosheets enabled highly sensitive and selective detection of NIF, with photoluminescence spectroscopy revealing a broad linear detection range of 0.6–360 nM (R² = 0.993) and an exceptionally low limit of detection (LOD) of 0.40 nM. The system showed high selectivity toward NIF over structurally similar compounds, drugs, and common metal ions. The sensor was effectively applied for the detection of NIF in urine and Lotus Pond water samples, highlighting its potential for practical pharmacological monitoring. This study presents a sustainable and effective approach for fabricating DES-assisted 2D nanosheets for trace-level analyte detection. 2026-10-01T00:00:00Z Text Journal contribution 10.1021/acs.analchem.6c02269.s001 https://figshare.com/articles/journal_contribution/DES-Based_Green_Synthesis_of_2D_Fluorescent_Molybdenum_Disulfide_for_Highly_Sensitive_and_Selective_Detection_of_Nifedipine/34046048 CC BY-NC 4.0