2026-10-11T11:01:48Z https://api.figshare.com/v2/oai

oai:figshare.com:article/34044533 2026-10-01T11:24:27Z category_4 category_13 category_14 category_19 category_21 category_873 category_734 portal_87 item_type_1 month_year_10_2026

Chemical composition, anti-adipogenic effects and molecular interactions of <i>Syzygium claviflorum</i> fruit essential oil Nurunajah Ab Ghani (4586425) Wan Mohd Nuzul Hakimi Wan Salleh (6902981) Abubakar Siddiq Salihu (14634083) Faezatul Alwani Mohd Rahim (21672708) Nur Nabilah Mohd Zaini (17347953) Rozaini Mohd Zohdi (25156319) Farkhod Eshboev (23127825) Sherali Kuziev (23127828) Feruzbek Khasanov (23127831) Biochemistry Genetics Molecular Biology Pharmacology Biotechnology Chemical Sciences not elsewhere classified Biological Sciences not elsewhere classified Myrtaceae Syzygium Syzygium claviflorum Anti-adipogenic Essential oil <p>Obesity is a global health concern associated with metabolic disorders such as type-2 diabetes and cardiovascular diseases. It results from excessive adipogenesis, regulated by key transcription factors PPARγ, C/EBPα, and SREBP-1, leading to fat accumulation. Due to the side effects of synthetic anti-obesity drugs, natural plant-based alternatives are gaining interest. This study evaluates the anti-adipogenic potential of <i>Syzygium claviflorum</i> essential oil using <i>in vitro</i> and <i>in silico</i> approaches. Hydrodistillation of <i>S. claviflorum</i> fruit oil had afforded a total of 23 components, representing 98.7% of the total composition. The major components were α-cadinol (26.7%), τ-muurolol (16.6%), <i>epi</i>-α- cadinol(11.4%), α-muurolene (8.4%), γ-muurolene (6.6%). The essential oil significantly reduced lipid accumulation in a dose-dependent manner, with 63.33% reduction at 50 µg/mL, comparable to NAC, a known adipogenesis inhibitor. qRT- PCR analysis demonstrated essential oil downregulated adipogenic transcription factors, particularly PPARγ (58.4%), C/EBPα (55.8%), and SREBP-1 (47.3%), along with lipid metabolism genes FAS, ACC, and aP2. Molecular docking confirmed that t-muurolol and <i>epi</i>-α-cadinol exhibited strong binding affinities with PPARγ, forming hydrophobic (π-alkyl, alkyl) interactions, potentially disrupting adipogenic signaling. These findings suggest the essential oil possesses anti- adipogenic activity and may serve as a natural anti-obesity agent.</p> 2026-10-01T11:24:27Z Image Figure 10.6084/m9.figshare.34044533.v1 https://figshare.com/articles/figure/Chemical_composition_anti-adipogenic_effects_and_molecular_interactions_of_i_Syzygium_claviflorum_i_fruit_essential_oil/34044533 CC BY 4.0