2026-10-12T07:48:58Z https://api.figshare.com/v2/oai

oai:figshare.com:article/34044510 2026-10-01T11:19:37Z category_7 category_21 category_734 category_61 category_64 portal_87 item_type_6 month_year_10_2026

Modified CONUT score integrating C-reactive protein improves prognostic prediction in non-small cell lung cancer Xiang-Ting Dai (25156272) Xiu-Xiu Li (17295412) Xi Zhang (83736) Jia-Xin Huang (5896760) Min Yang (146229) Meng Tang (139012) Chun-Hua Song (11416637) Wei Li (7081) Han-Ping Shi (8897111) Ming-Hua Cong (11228853) Medicine Biotechnology Biological Sciences not elsewhere classified Developmental Biology Cancer Modified controlling nutritional status controlling nutritional status systemic inflammation NSCLC prognosis <p>Non-small cell lung cancer (NSCLC) remains a leading cause of cancer-related mortality worldwide, highlighting the need for reliable prognostic indicators. The modified Controlling Nutritional Status (mCONUT) score integrates nutritional and inflammatory parameters. This study evaluated the prognostic value of mCONUT in NSCLC and developed an mCONUT-based nomogram.</p> <p>This multicenter cohort study included 900 patients with NSCLC. The previously reported CRP-integrated mCONUT scoring system was applied. The prognostic performance of CONUT and mCONUT was compared using concordance index, time-dependent receiver operating characteristic (ROC) curves, net reclassification improvement (NRI), and integrated discrimination improvement (IDI). Overall survival (OS) was the primary endpoint. Secondary outcomes included short-term survival, malnutrition, and quality of life. A nomogram was constructed based on independent prognostic factors.</p> <p>During a median follow-up of 33.4 months, 380 deaths occurred. mCONUT showed a higher C-index than CONUT for OS prediction (0.650 vs. 0.605). A high mCONUT score was independently associated with poorer OS (HR = 1.63, 95% CI: 1.28–2.06), increased short-term mortality, an increased risk of malnutrition, and worse quality of life. The mCONUT-based nomogram showed improved discrimination (C-index = 0.727).</p> <p>mCONUT may serve as a supplementary prognostic tool for individualized risk stratification in patients with NSCLC.</p> 2026-10-01T11:19:37Z Text Journal contribution 10.6084/m9.figshare.34044510.v1 https://figshare.com/articles/journal_contribution/Modified_CONUT_score_integrating_C-reactive_protein_improves_prognostic_prediction_in_non-small_cell_lung_cancer/34044510 CC BY 4.0