2026-10-11T20:39:05Z https://api.figshare.com/v2/oai

oai:figshare.com:article/34044445 2026-10-01T11:16:51Z category_4 category_7 category_12 category_13 category_14 category_16 category_873 category_45 category_734 category_64 portal_63 item_type_6 month_year_10_2026

Metabolite-Associated Inflammation during Combined Exposure to Cooking Oil Fumes and Atopic Dermatitis: A Multi-Organ Spatial Metabolomics Study Bailiang Liu (13998524) Chihang Zhang (25156240) Xiyuan Zhang (4222438) Jiajing Li (5546384) Jinzhuo Zhao (2578108) Lidia Morawska (1445458) Lina Wang (44695) Biochemistry Medicine Cell Biology Genetics Molecular Biology Physiology Chemical Sciences not elsewhere classified Sociology Biological Sciences not elsewhere classified Cancer largest systemic increases identify candidate pathways cooking oil fumes cooking oil fume tricarboxylic acid cycle mitochondrial respiratory assays concentration cof regimen cof group showed spatial lipid remodeling observed across blood establish metabolite transport uric acid spatial metabolomics respiratory barriers lipid metabolism succinate accumulation situ immunofluorescence several features receptor blockade pronounced changes pentose phosphate organ metabolites organ framework mouse model metabolite tracing kidney changes integrated untargeted functional validation coordinated disturbance controlled high concurrent impairment characterize lung causal signaling based cross atopic dermatitis adp measurements How the concurrent impairment of the skin and respiratory barriers is associated with distal-organ injury remains unclear. Here, we integrated untargeted and spatial metabolomics with in situ immunofluorescence to characterize lung-blood-heart-kidney changes in a mouse model of atopic dermatitis (AD) and cooking oil fume (COF) co-exposure. The AD+COF group showed the largest systemic increases in IL-6 and TNF-alpha and the most pronounced changes in circulating and organ metabolites. Succinate accumulation, depletion of xanthine and uric acid, glucose-related perturbations, and spatial lipid remodeling were observed across blood, lungs, heart, and kidneys, and several features were strongly correlated across compartments. These patterns are consistent with coordinated disturbance of tricarboxylic acid cycle-related, pentose phosphate, purine, and membrane-lipid metabolism. Because metabolite tracing, receptor blockade, ATP/ADP measurements, and mitochondrial respiratory assays were not performed, the data do not establish metabolite transport or causal signaling between organs. Instead, they support an association-based cross-organ framework and identify candidate pathways for functional validation. Environmental extrapolation also requires caution because a controlled high-concentration COF regimen was used. 2026-10-01T00:00:00Z Text Journal contribution 10.1021/acs.est.6c11745.s001 https://figshare.com/articles/journal_contribution/Metabolite-Associated_Inflammation_during_Combined_Exposure_to_Cooking_Oil_Fumes_and_Atopic_Dermatitis_A_Multi-Organ_Spatial_Metabolomics_Study/34044445 CC BY-NC 4.0