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oai:figshare.com:article/34044235 2026-10-01T11:11:31Z category_4 category_146 category_7 category_8 category_14 category_24 category_873 category_39 category_135 portal_63 item_type_6 month_year_10_2026

Atroposelective Desymmetrizing Iodination via Chiral Phosphoric Acid Catalysis: Synthesis of Axially Chiral Biaryl Phosphine Oxides Yan Chang (486484) Yushen Gao (25156222) Xinghua Wang (1672573) An-An Zhang (1608607) Mingliang Zhang (104816) Gaowei Li (8795693) Bing-Bing Song (5113409) Yuan-Yuan Gao (5904737) Qiuling Song (1393048) Lantao Liu (104405) Biochemistry Space Science Medicine Microbiology Molecular Biology Evolutionary Biology Chemical Sciences not elsewhere classified Ecology Computational Biology diverse substitution patterns catalyzed atroposelective iodination tert </ reaction proceeds method accommodates iodinating reagent external additives excellent yields donor substituents di -< aromatic rings >- butyl Herein, we report a CPA-catalyzed atroposelective iodination of prochiral phosphine oxides bearing no hydrogen-bond-donor substituents, affording a range of 3′-iodinated axially chiral biaryl phosphine oxides in excellent yields and enantioselectivities. The reaction proceeds through synergistic noncovalent interactions among the iodinating reagent, the catalyst, and the substrate, eliminating the need for substrate pre-functionalization or external additives. The method accommodates both di-<i>tert</i>-butyl and dicyclohexyl phosphine oxide substrates, as well as diverse substitution patterns on both aromatic rings. 2026-10-01T00:00:00Z Text Journal contribution 10.1021/acs.orglett.6c03558.s001 https://figshare.com/articles/journal_contribution/Atroposelective_Desymmetrizing_Iodination_via_Chiral_Phosphoric_Acid_Catalysis_Synthesis_of_Axially_Chiral_Biaryl_Phosphine_Oxides/34044235 CC BY-NC 4.0