2026-10-10T16:14:59Z https://api.figshare.com/v2/oai

oai:figshare.com:article/34043313 2026-10-01T10:51:05Z category_7 portal_147 item_type_3 month_year_10_2026

Supplemental Material for: Transjugular intrahepatic portosystemic shunt versus endoscopic treatment for variceal rebleeding: a systematic review and meta-analysis figshare admin karger (2628495) Le Wang (165105) Jiaorong Qu (20491312) Xuejing Jin (5151623) Runping Liu (535257) Zhiyun Yang (3775975) Xiaojiaoyang Li (8790515) Medicine Medicine <p dir="ltr">Introduction: Both transjugular intrahepatic portosystemic shunt (TIPS) and endoscopic therapy (ET) are effective for managing variceal rebleeding in cirrhosis. This study aimed to evaluate TIPS versus ET in rebleeding prevention, mortality reduction and associated complications.</p><p dir="ltr">Methods: A systematic search of PubMed, Embase, Web of Science, Scopus and the Cochrane Library was performed to identify randomized controlled trials (RCTs) comparing TIPS versus ET for meta-analysis.</p><p dir="ltr">Results: This study has been registered in PROSPERO (CRD42024592387). Data were extracted from 23 RCTs, including 1860 patients. Compared to the ET group, patients in the TIPS group exhibited a lower rate of variceal rebleeding (RR, 0.39; 95% CI, 0.33 to 0.47). The incidence of ascites (RR, 0.40; 95% CI, 0.28 to 0.58), spontaneous bacterial peritonitis (RR, 0.42; 95% CI, 0.19 to 0.91) and hepatorenal syndrome (RR, 0.35; 95% CI, 0.17 to 0.71) were lower in the TIPS group. The use of covered stent (RR, 0.63; 95% CI, 0.45 to 0.89) and early TIPS (RR, 0.67; 95% CI, 0.46 to 0.98) were associated with reduced mortality. For hepatic encephalopathy (HE), early TIPS did not significantly increase the risk (RR, 1.27; 95% CI, 0.84 to 1.90).</p><p dir="ltr">Conclusion: In conclusion, TIPS significantly reduced variceal rebleeding and complications including ascites, spontaneous bacterial peritonitis and hepatorenal syndrome. The use of bare stent and non-early TIPS was correlated with poorer survival. Moreover, early TIPS significantly reduced mortality without elevating HE.</p> 2026-10-01T10:51:05Z Dataset Dataset 10.6084/m9.figshare.34043313.v1 https://figshare.com/articles/dataset/Supplemental_Material_for_Transjugular_intrahepatic_portosystemic_shunt_versus_endoscopic_treatment_for_variceal_rebleeding_a_systematic_review_and_meta-analysis/34043313 CC BY 4.0